6338-36-9

Usage

Appearance

White crystalline

Natural occurrence

Not naturally occurring

Parent compound

Isosorbide (a six-membered sugar alcohol)

Derivative

Di-benzylated derivative

Usage

Intermediate in the synthesis of various pharmaceuticals

Applications

Cardiovascular and diuretic pharmaceuticals

Additional uses

Starting material in the manufacture of specialty polymers and resins

Structure

Unique structure useful in the development of new materials and pharmaceuticals with specific properties and applications.

Upstream product

• 100-44-7 benzyl chloride 
• 641-74-7 1,4:3,6-dianhydro-D-mannitol 
• 652-67-5 Isosorbide 
• 100-39-0 benzyl bromide 

Downstream Products

• 1228508-01-7 3-[(2S,5R)-3-phenyl-1,3-diaza-2-phosphabicyclo[3.3.0]oct-2-yloxy]-6-benzyloxy-(3R,3aS,6R,6aR)-hexahydrofuro[3,2-b]-furan 
• 1228508-02-8 3-[(2R,5S)-3-phenyl-1,3-diaza-2-phosphabicyclo[3.3.0]oct-2-yloxy]-6-benzyloxy-(3R,3aS,6R,6aR)-hexahydrofuro[3,2-b]-furan 

Relevant academic research and scientific papers

Synthesis of novel chiral imidazolium-based ionic liquids derived from isosorbide and their applications in asymmetric aza Diels-Alder reaction

A novel family of chiral imidazolium-based ionic liquids containing a chiral moiety and a free hydroxyl function has been designed and synthesized using isosorbide as a biorenewable substrate. These chiral ionic liquids were found to catalyze the aza Diels-Alder reaction to give good yields and moderate diastereoselectivities. Chiral ionic liquids are recycled while their efficiency is preserved.

Chiral ionic liquids derived from isosorbide: Synthesis, properties and applications in asymmetric synthesis

A novel class of chiral ammonium and imidazolium-based ionic liquids has been designed and synthesized using isosorbide as a biorenewable substrate. These chiral ionic liquids were found to catalyze the aza Diels-Alder reaction to give good yields and moderate diastereoselectivitives.

Ethers of bisanhydrohexitols

A novel method for the synthesis of ethers of anhydrosugars, such as isosorbide, isomannide, and isoidide, is disclosed. The bisglycidyl ethers are useful as substitutes for bisphenol A in the manufacture of thermoset epoxy ethers. Anhydrosugar ethers are

Selective alkylations of 1,4:3,6-dianhydro-D-glucitol (isosorbide)

Each of the two hydroxyl groups of isosorbide can be alkylated selectively, either by direct alkylation with benzyl chloride or allyl bromide according to the reaction conditions, or by a three-step procedure involving selective monoacetylation, alkylation with four different reagents, and finally deacetylation.Monobutyl and monomethyl derivatives from isosorbide are also described.