6338-63-2

Basic information

• Product Name: 2-PHENOXYETHANETHIOL
• Synonyms: 2-phenoxyethane-1-thiol
• CAS NO: 6338-63-2
• Molecular Formula: C₈H₁₀OS
• Molecular Weight: 154.23
• Product Categories: Organic Building Blocks;Sulfur Compounds;Thiols/Mercaptans
• Mol File: 6338-63-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 201-202 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.105 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.058mmHg at 25°C
• Refractive Index: n20/D 1.5600(lit.)
• PKA: 9.68±0.10(Predicted)
• CAS DataBase Reference: 2-PHENOXYETHANETHIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENOXYETHANETHIOL(6338-63-2)
• EPA Substance Registry System: 2-PHENOXYETHANETHIOL(6338-63-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 6338-63-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H10OS/c10-7-6-9-8-4-2-1-3-5-8/h1-5,10H,6-7H2

Upstream product

• 60359-72-0 thioacetic acid S-(2-phenoxy-ethyl ester) 
• 122-99-6 2-Phenoxyethanol 
• 420-12-2 thirane 
• 123-91-1 1,4-dioxane 
• 7647-01-0 hydrogenchloride 
• 766-94-9 vinyl phenyl ether 
• 7783-06-4 hydrogen sulfide 
• 16654-50-5 S-(2-Phenoxy-aethyl)-O-aethyl-xanthogenat 
• 589-10-6 phenoxyethyl bromide 
• 108-95-2 phenol 

Downstream Products

• 16654-62-9 2-Phenoxy-aethyl-trimethylsilylsulfid 
• 1404074-69-6 2,3-bis(2-phenoxyethylthio)naphthalene-1,4-dione 
• 1351935-95-9 8-[(2-phenoxyethyl)sulfanyl]caffeine 
• 1049095-40-0 3-[4-Chloro-3-(2-phenoxy-ethylsulfanyl)-phenyl]-5-methanesulfonyl-1-(3-morpholin-4-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 
• 1092979-22-0 (2-phenoxyethyl)(1-phenylvinyl)sulfane 
• 119786-24-2 <1α,2α(Z),3α,4α>-(+/-)-7-<3-<<(2-Phenoxyethyl)thio>methyl>-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptenoic acid 

Relevant articles and documents

Thioacetate deprotection

A method of thioacetate deprotection by providing a compound of the formula R1—S—CO—R2, and reacting the compound with a quaternary ammonium cyanide salt in the presence of a protic solvent in an inert atmosphere to convert the compound to a product of the formula R1—SH. R1 is an organic group in which the bonding to sulfur is through a saturated carbon, and R2 is an aliphatic group.

Aliphatic thioacetate deprotection using catalytic tetrabutylammonium cyanide

A series of thiol-functionalized organic compounds were selected to analyze the scope and efficiency of a new thioacetate deprotection method using catalytic tetrabutylammonium cyanide (TBACN) to effect the transformation of a thioacetate group to a free thiol in the presence of a protic solvent. Particularly attractive are the mild reaction and workup conditions, reduced byproduct formation typically seen using literature methods and yields of greater than 80% for the free aliphatic thiols. This method is effective on aliphatic thiols with trityl, benzyl, p-halo-benzyl, phenethyl, phenoxyethyl, and cyclohexylethyl structural moieties, but it is not effective with thiophenols.