6338-63-2

Usage

InChI:InChI=1/C8H10OS/c10-7-6-9-8-4-2-1-3-5-8/h1-5,10H,6-7H2

Upstream product

• 420-12-2 thirane 
• 108-95-2 phenol 
• 766-94-9 vinyl phenyl ether 
• 60359-72-0 thioacetic acid S-(2-phenoxy-ethyl ester) 
• 589-10-6 phenoxyethyl bromide 
• 16654-50-5 S-(2-Phenoxy-aethyl)-O-aethyl-xanthogenat 
• 123-91-1 1,4-dioxane 
• 7647-01-0 hydrogenchloride 
• 7783-06-4 hydrogen sulfide 
• 122-99-6 2-Phenoxyethanol 

Downstream Products

• 16654-62-9 2-Phenoxy-aethyl-trimethylsilylsulfid 
• 119786-24-2 <1α,2α(Z),3α,4α>-(+/-)-7-<3-<<(2-Phenoxyethyl)thio>methyl>-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptenoic acid 
• 1092979-22-0 (2-phenoxyethyl)(1-phenylvinyl)sulfane 
• 1049095-40-0 3-[4-Chloro-3-(2-phenoxy-ethylsulfanyl)-phenyl]-5-methanesulfonyl-1-(3-morpholin-4-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 
• 1351935-95-9 8-[(2-phenoxyethyl)sulfanyl]caffeine 
• 1404074-69-6 2,3-bis(2-phenoxyethylthio)naphthalene-1,4-dione 

Relevant academic research and scientific papers

Thioacetate deprotection

A method of thioacetate deprotection by providing a compound of the formula R1—S—CO—R2, and reacting the compound with a quaternary ammonium cyanide salt in the presence of a protic solvent in an inert atmosphere to convert the compound to a product of the formula R1—SH. R1 is an organic group in which the bonding to sulfur is through a saturated carbon, and R2 is an aliphatic group.

5-HYDROXYINDOLE-3-CARBOXYLATES DERIVATIVES AND THEIR USE

The present invention relates to 5-hydroxy-indole-3-carboxylate derivatives of formula I , or racemic mixture or optical isomers or pharmaceutically acceptable salts and/or hydrates thereof, wherein: substitutents R 1 , R 2 , Z, X and Y are as defined in the description. The compounds of formula I can be useful for preparation of medicament for treatment and/or prophylaxis of virus infections, especially for preparation of medicament for anti-HBV (Hepatitis B virus) and anti-HIV (Human immunodeficiency virus).

Aliphatic thioacetate deprotection using catalytic tetrabutylammonium cyanide

A series of thiol-functionalized organic compounds were selected to analyze the scope and efficiency of a new thioacetate deprotection method using catalytic tetrabutylammonium cyanide (TBACN) to effect the transformation of a thioacetate group to a free thiol in the presence of a protic solvent. Particularly attractive are the mild reaction and workup conditions, reduced byproduct formation typically seen using literature methods and yields of greater than 80% for the free aliphatic thiols. This method is effective on aliphatic thiols with trityl, benzyl, p-halo-benzyl, phenethyl, phenoxyethyl, and cyclohexylethyl structural moieties, but it is not effective with thiophenols.

Ring opening reactions of thiiranes by alkoxo- and aryloxo-gold(I) complexes

Alkoxo- and aryloxo-gold(I) complexes [Au(OR)L] [R = CH(CF3)2, L = PPh3 1a or PCy3 1b; R = Ph, L = PPh3 1c, PCy3 1d or PMe3 1e] smoothly reacted with ethylene sulfide to give the corresponding 2-(alkoxy- or -aryloxy)ethyl-sulfanylgold(I) complexes [Au(SCH2CH2OR)L] 2 at room temperature. Similar treatments of 1a-1e with propylene sulfide, isobutylene sulfide, or styrene sulfide selectively cleaved the less hindered C-S bond of thiiranes to give corresponding 2-(alkoxy- or -aryloxy)ethylsulfanylgold(I) complexes. Reactions of 1a with cis- and trans-2-butene sulfide gave syn- and anti-[Au(SCHMeCHMeOR)L], respectively, suggesting a mechanism involving an SN2 type trans addition of alkoxogold(I) complexes toward thiiranes. The Royal Society of Chemistry 1999.