63382-85-4

Upstream product

• 3282-30-2 pivaloyl chloride 
• 74-99-7 prop-1-yne 
• 71-43-2 benzene 
• 32398-67-7 4,4-dimethyl-1-phenyl-1-pentyn-3-one 
• 15681-48-8 lithium dimethylcuprate 
• 1184-53-8 methylcopper 
• 22591-21-5 1,1-dichloro-3,3-dimethylbutan-2-one 
• 98-86-2 acetophenone 
• 30263-65-1 1,1-dibromo-3,3-dimethylbutan-2-one 
• 917-92-0 3,3-Dimethylbut-1-yne 
• 1196-67-4 (E)-β-methylcinnamaldehyde 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 4440-01-1 lithium phenylacetylide 
• 152876-60-3 ethyl (2Z)-3-iodo-3-phenylprop-2-enoate 

Relevant academic research and scientific papers

Metal- and Reagent-Free Intramolecular Oxidative Amination of Tri- and Tetrasubstituted Alkenes

A metal- and reagent-free, electrochemical intramolecular oxidative amination reaction of tri- and tetrasubstituted alkenes has been developed. The electrosynthetic method proceeds through radical cyclization to form the key C-N bond, allowing a variety of hindered tri- and tetrasubstituted olefins to participate in the amination reaction. The result is the efficient synthesis of a host of alkene-bearing cyclic carbamates and ureas and lactams.

One-Pot Synthesis of β,β-Disubstituted α,β-Unsaturated Carbonyl Compounds

TiCl4-promoted aldol reaction of ketones as aldol acceptors followed by elimination of the titanoxy group from the Ti-aldolates affords β,β-disubstituted α,β-unsaturated carbonyl compounds in a one-pot procedure. The use of additives, such as DMF, N,N,N′,N′-tetramethylethylenediamine, and pyridine, in the elimination step was found to be important.

Preparation and decarboxylative rearrangement of (Z)-enyne esters

A method to assemble (Z)-enyne esters via palladium-catalyzed cross coupling reactions of enol tosylates is reported. A base-mediated one-pot decarboxylative rearrangement of the enynes to enones is described. The scope of this process is examined.

Functional Group Hybrids. Reactivity of α'-Nucleofuge α,β-Unsaturated Ketones. 1. Reactions with Organocopper Reagents

A series of α-nucleofuge α',β'-unsaturated ketones encompassing a variety of structural types and nucleofuges was prepared.Treatment of these compounds with lithium dimethylcuprate or methylcopper leads primarily to either reductive cleavage of the α-nucl

REACTIONS OF POLYHALOGENATED FUNCTIONAL COMPOUNDS WITH METALS AND ELECTROPHILIC REAGENTS. XIV. REACTION OF 2,2-DIHALOGENOPINACOLINES WITH ZINC AND CARBONYL COMPOUNDS

A new method was developed for the production of the E forms of α,β-unsaturated ketones on the basis of the reaction of 2,2-dibromo- and 2,2-dichloropinacolines, zinc, and carbonyl compounds.