63382-85-4

Upstream product

• 3282-30-2 pivaloyl chloride 
• 74-99-7 prop-1-yne 
• 71-43-2 benzene 
• 4440-01-1 lithium phenylacetylide 
• 1196-67-4 (E)-β-methylcinnamaldehyde 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 98-86-2 acetophenone 
• 152876-60-3 ethyl (2Z)-3-iodo-3-phenylprop-2-enoate 
• 917-92-0 3,3-Dimethylbut-1-yne 
• 30263-65-1 1,1-dibromo-3,3-dimethylbutan-2-one 
• 22591-21-5 1,1-dichloro-3,3-dimethylbutan-2-one 
• 32398-67-7 4,4-dimethyl-1-phenyl-1-pentyn-3-one 
• 1184-53-8 methylcopper 
• 15681-48-8 lithium dimethylcuprate 

Relevant academic research and scientific papers

Metal- and Reagent-Free Intramolecular Oxidative Amination of Tri- and Tetrasubstituted Alkenes

A metal- and reagent-free, electrochemical intramolecular oxidative amination reaction of tri- and tetrasubstituted alkenes has been developed. The electrosynthetic method proceeds through radical cyclization to form the key C-N bond, allowing a variety of hindered tri- and tetrasubstituted olefins to participate in the amination reaction. The result is the efficient synthesis of a host of alkene-bearing cyclic carbamates and ureas and lactams.

One-Pot Synthesis of β,β-Disubstituted α,β-Unsaturated Carbonyl Compounds

TiCl4-promoted aldol reaction of ketones as aldol acceptors followed by elimination of the titanoxy group from the Ti-aldolates affords β,β-disubstituted α,β-unsaturated carbonyl compounds in a one-pot procedure. The use of additives, such as DMF, N,N,N′,N′-tetramethylethylenediamine, and pyridine, in the elimination step was found to be important.

Preparation and decarboxylative rearrangement of (Z)-enyne esters

A method to assemble (Z)-enyne esters via palladium-catalyzed cross coupling reactions of enol tosylates is reported. A base-mediated one-pot decarboxylative rearrangement of the enynes to enones is described. The scope of this process is examined.

REACTIONS OF POLYHALOGENATED FUNCTIONAL COMPOUNDS WITH METALS AND ELECTROPHILIC REAGENTS. XIV. REACTION OF 2,2-DIHALOGENOPINACOLINES WITH ZINC AND CARBONYL COMPOUNDS

A new method was developed for the production of the E forms of α,β-unsaturated ketones on the basis of the reaction of 2,2-dibromo- and 2,2-dichloropinacolines, zinc, and carbonyl compounds.

Functional Group Hybrids. Reactivity of α'-Nucleofuge α,β-Unsaturated Ketones. 1. Reactions with Organocopper Reagents

A series of α-nucleofuge α',β'-unsaturated ketones encompassing a variety of structural types and nucleofuges was prepared.Treatment of these compounds with lithium dimethylcuprate or methylcopper leads primarily to either reductive cleavage of the α-nucl