6342-17-2

Basic information

• Product Name: 1,4-Diacryloylpiperazine
• Synonyms: DIACRYLYL-PIPERAZINE;BAP;1,4-DIACRYLOYLPIPERAZINE;1,4-DIACRYLYLPIPERAZINE;1,4-BIS(ACRYLOYL)PIPERAZINE;N,N'-DIACRYLOYLPIPERAZINE;N,N'-BISACRYLOYLPIPERAZINE;PDA
• CAS NO: 6342-17-2
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.23
• EINECS: 613-215-5
• Product Categories: Nitric Oxide Reagents;Electrophoresis Materials;Cross Linking Reagents;Gel Casting Reagents;Gel Cross-Linkers;Building Blocks;C10;Chemical Synthesis;Heterocyclic Building Blocks;Piperazines;Protein Electrophoresis;Proteomics;SDS-PAGE;MTS & Sulfhydryl Active Reagents;gel;CMLLYL
• Mol File: 6342-17-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 91.5-93.5 °C(lit.)
• Boiling Point: 434.1 °C at 760 mmHg
• Flash Point: 216.5 °C
• Appearance: /
• Density: 1.114 g/cm³
• Vapor Pressure: 9.73E-08mmHg at 25°C
• Refractive Index: 1.516
• Storage Temp.: 2-8°C
• PKA: -0.70±0.70(Predicted)
• BRN: 745431
• CAS DataBase Reference: 1,4-Diacryloylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Diacryloylpiperazine(6342-17-2)
• EPA Substance Registry System: 1,4-Diacryloylpiperazine(6342-17-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: UD6715000
• F: 8
• Hazardous Substances Data: 6342-17-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

Uses

Different sources of media describe the Uses of 6342-17-2 differently. You can refer to the following data:
1. Used as a crosslinker in polyacrylamide gels. PIP provides polyacrylamide gels with increased physical strength and improved separation and detection of proteins.
2. 1,4-Diacryloylpiperazine is used as a crosslinker in polyacrylamide gels. PIP provides polyacrylamide gels with increased physical strength and improved separation and detection of proteins
3. Suitable for preparation of gels for PAGE, IEF, 2D electrophoresis and protein sequencing.

General Description

1,4-Bis(acryloyl)piperazine is a reagent that can be substituted for bis-acrylamide in the preparation of polyacrylamide gels.

InChI:InChI=1/C10H14N2O2/c1-3-9(13)11-5-7-12(8-6-11)10(14)4-2/h3-4H,1-2,5-8H2

Upstream product

• 110-85-0 piperazine 
• 79-10-7 acrylic acid 
• 814-68-6 acryloyl chloride 
• 32586-73-5 N,N'-bis(morpholinopropionyl)piperazine 
• 108-24-7 acetic anhydride 

Downstream Products

• 1422359-91-8 C₁₄H₂₄N₄O₂ 
• 1422359-92-9 C₁₅H₂₆N₄O₂ 
• 497147-13-4 G₁-(OH)₄ 
• 497147-15-6 G₂-(OH)₈ 

Relevant articles and documents

COMPOSES CETONIQUES SUPPORTES CATALYSEURS D'HYDRATATION DES α-AMINONITRILES

The preparation of hydrophilic crosslinked polymers which are carrying carbonyl groups of the 4-piperidone type is described.These compounds catalyse the hydration of α-aminonitriles to α-aminoamides.The main parameters involved in the catalytic activity are studied.

Preparation method of acrylamide-based compounds

The present invention relates to the field of fine chemical materials, particularly to a new mild, efficient and economical preparation process technology of a class of acrylamide-type compounds, wherein a beta-amine substituted propionamide precursor is subjected to an in-situ amine elimination reaction under the action of a suitable electrophilic reagent so as to prepare the target product.

Total synthesis of amiclenomycin, an inhibitor of biotin biosynthesis.

We describe the first synthesis of amiclenomycin, a natural product that has been found to inhibit biotin biosynthesis and, as a consequence, to exhibit antibiotic properties. Structure 1, with a trans relationship between the ring substituents. had previously been proposed for amiclenomycin on the basis of its 1H NMR spectrum. We have prepared the trans and cis isomers 1 and 2 by unequivocal routes and we conclude that the natural product is in fact the cis isomer 2. The properly substituted cyclohexadienyl rings were constructed first. A cycloaddition reaction between 1,2-di(phenylsulfonyl)ethylene and the N-allyloxycarbonyl diene 13, followed by reductive elimination of the phenylsulfinyl groups, gave the cis isomer 15. To obtain the trans isomer, the O-trimethylsilyl diene was used to give the cis hydroxylated Diels-Alder adduct 33, which was transformed into the corresponding trans amino derivative by means of a Mitsunobu reaction. The L-alpha-amino acid functionality was introduced by means of a Strecker reaction on the aldehydes 16 and 42, followed by enzymatic hydrolysis with immobilised pronase.