6342-46-7

Usage

Uses

Used in Pharmaceutical Industry:
N'-(4-CHLOROBENZYLIDENE)ISONICOTINOHYDRAZIDE is used as a drug candidate for its potential anti-inflammatory and antitumor properties, and for the treatment of various diseases.
Used in Cancer Therapy:
N'-(4-CHLOROBENZYLIDENE)ISONICOTINOHYDRAZIDE is used as a potential agent for inhibiting the growth of certain cancer cells and may have applications in cancer therapy.
Used in Antimicrobial Applications:
N'-(4-CHLOROBENZYLIDENE)ISONICOTINOHYDRAZIDE is used as a potential agent for the development of new drugs to combat antibiotic resistance due to its antimicrobial activity.

Upstream product

• 54-85-3 isoniazid 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 586-95-8 pyridine-4-methanol 
• 104-86-9 4-chlorobenzylamine 
• 382178-47-4 2-(4-chlorophenyl)-3-acetyl-5-(pyridin-4-yl)-2,3-dihydro-1,3,4-oxadiazole 
• 79844-21-6 N-[2-(4-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide 
• 1152134-78-5 N-[3-chloro-2-(4-chlorophenyl)-4-oxoazetidin-1-yl]isonicotinamide 

Relevant academic research and scientific papers

Synthesis, characterization, in silico studies and in vitro biological evaluation of isoniazid-hydrazone complexes

Isoniazid-hydrazone complexes (IHCs) were synthesized and thoroughly characterized by FT-IR, 1H NMR and 13C NMR spectroscopic techniques. The anti-inflammatory and antidiabetic activities were tested for the IHCs using protein denatu

(Hetero-)(arylidene)arylhydrazides as Multitarget-Directed Monoamine Oxidase Inhibitors

Fourteen (hetero-)(arylidene)arylhydrazide derivatives (ABH1-ABH14) were synthesized, and their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE) were evaluated. Compound ABH5 most potently inhibited MAO-B with an IC5

Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides: A systematic approach from in vitro, in silico to in vivo studies

Change in life style and eating habits has led to an increased prevalence of hyperuricemia worldwide. The role of hyperuricemia is no more restricted to gout, but it has a central role in progression of CVD, hypertension, metabolic syndrome, and arthritis

Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5′-nucleotidase

A series of isonicotinohydrazide derivatives was synthesized and tested against recombinant human and rat ecto-5′-nucleotidases (h-e5′NT and r-e5′NT) and alkaline phosphatase isozymes including both bovine tissue-non-specific alkaline phosphatase (b-TNAP)

Eco-friendly and highly efficient synthesis, including multigram synthesis, of aldehyde isonicotinoyl hydrazones using sonochemistry

Background: The isoniazid has been a key compound in first-line tuberculosis (TB) treatment, usually in combination with other drugs. Following on from the use of isoniazid itself, various derivatives of isoniazid have also been investigated as anti-TB ag

Synthesis and antimicrobial activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide

A series of isonicotinyl hydrazones and their 4-thiazolidinones have been synthesized by condensation of isonicotinic acid hydrazide with various aromatic aldehydes to yield Schiff's bases, followed by the cyclocondensation of Schiff's bases with 2-mercaptoacetic acid to yield their 4-thiazolidinones. The synthesized compounds have been characterized by their elemental, analytical and spectral studies. All these compounds were evaluated for their invitro antimicrobial activity against a spectrum of non-resistant and resistant microbial organisms. These studies proved that compounds 5e,i against B. subtilis; 5e,f,h against B. anthracis; 5g,i against S. aureus showed good activity at lower concentrations. Compounds 5d-5i displayed significant activity against resistant strain of K. pneumonia with minimum inhibitory potency in the concentration range of 2-16 ug/ml.

Design and synthesis of novel N-substituted-3-chloro-2- azetidinone derivatives as potential anticonvulsant agents

A new series of N-[3-chloro-2-(substitutedphenyl)-oxo-azetidin-1-yl] isonicotinamide (2a-l) were synthesized through condensation reaction of isoniazide with substituted aldehyde. The newly synthesized compounds ere characterized by spectral data (IR, su

Thiazolidin-4-one, azetidin-2-one and 1,3,4-oxadiazole derivatives of isonicotinic acid hydrazide: Synthesis and their biological evaluation

A series of thiazolidin-4-one (2a-h; 3a-h), azetidin-2-one (4a-h) and 1,3,4-oxadiazole (5a-h) derivatives of isoninicotinic acid hydrazide (INH) were synthesized in order to obtain new compounds with potential anti-inflammatory, analgesic, ulcerogenic and

Synthesis and anti-mycobacterial activity of (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives

A series of 22 (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and

Polarographic and Cyclic Voltametric Reduction of p-Chlorobenzaldehyde Isonicotinoylhydrazone

p-Chlorobenzaldehyde isonicotinoylhydrazone (p-Cl-BAINH) exhibits a single wave in acid buffered solutions (pH 2-6) and two waves in alkaline buffered solutions (pH 7- 9).However, the compound exhibits three cathodic peaks in acid solution and two cathodic peaks in alkaline solutions.The electrode reactions are attributed to the reductive cleavage of =N-N- linkage and the reduction of the amide formed in the cleavage.