63438-53-9

Usage

Uses

Used in Pharmaceutical Industry:
Piracetam is used as a cognitive enhancer for improving memory and learning capabilities. Its application is based on its ability to modulate neurotransmission, which leads to enhanced cognitive function.
Used in Neurodegenerative Disorder Treatment:
Piracetam is used as a potential therapeutic agent for neurodegenerative disorders due to its neuroprotective and neurotrophic effects. The application is aimed at providing treatment options for conditions such as cognitive impairment and dementia.
Used in Research and Development:
Piracetam is used as a research compound for studying the mechanisms underlying cognitive enhancement, memory improvement, and the treatment of neurodegenerative diseases. Its application in this context is to advance the understanding of its effects and potential uses in various cognitive-related conditions.
Used in Animal Models:
Piracetam is used in animal models to study its effects on learning and memory. The application is to provide insights into its potential benefits and mechanisms of action in a controlled experimental setting.

InChI:InChI=1/C7H12N2O2/c1-9(2)7(11)5-3-4-6(10)8-5/h5H,3-4H2,1-2H3,(H,8,10)

Upstream product

• 16450-41-2 L-glutamic acid diethyl ester 
• 124-40-3 dimethyl amine 
• 98-79-3 L-Pyroglutamic acid 
• 4931-66-2 methyl (S)-pyroglutamate 

Downstream Products

• 1009093-79-1 (2S,5R)-tert-butyl 2-(dimethylcarbamoyl)-5-phenylpyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Synthesis and bioactivities evaluation of L-pyroglutamic acid analogues from natural product lead

A series of L-pyroglutamic acid analogues from natural product lead were designed and synthesized, as well as their antifungal activities against Phytophthora infestans, neuritogenic activities, antibacterial activities and anti-inflammatory activities are described. The bioassays and SAR study showed that the majority of L-pyroglutamic acid esters have a significant antifungal activity against P. infestans, especially 2d and 2j demonstrated the best activities with EC50 values of 1.44 and 1.21 μg mL?1, which were about seven times that of commercial azoxystrobin (7.85 μg mL?1). Moreover, compounds 2e, 2g and 4d displayed anti-inflammatory activity against LPS-induced NO production in BV-2 microglial cells; neuritogenic activity in NGF-induced PC-12 cells is the same activity. This study demonstrates that compounds 2d and 2j are potential drugs to control P. infestans.

Flexible and modular syntheses of enantiopure 5-cis-substituted prolinamines from l-pyroglutamic acid

A wide range (25 examples) of 5-cis-substituted prolinamines is prepared in five to ten steps starting from cheap l-pyroglutamic acid. Three routes, differing mainly in the order of introduction of the substituents at the 5-cis position, the pyrrolidine nitrogen atom, and the exocyclic amino function, are successfully developed.