6345-56-8

Basic information

• Product Name: 4-methylhexahydro-4,7-epoxy-2-benzofuran-1,3-dione
• Synonyms: 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-4-methyl-
• CAS NO: 6345-56-8
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.1733
• Mol File: 6345-56-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 339.7°C at 760 mmHg
• Flash Point: 154.1°C
• Density: 1.409g/cm³
• Vapor Pressure: 9.01E-05mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: 4-methylhexahydro-4,7-epoxy-2-benzofuran-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylhexahydro-4,7-epoxy-2-benzofuran-1,3-dione(6345-56-8)
• EPA Substance Registry System: 4-methylhexahydro-4,7-epoxy-2-benzofuran-1,3-dione(6345-56-8)

Safety Data

• Hazardous Substances Data: 6345-56-8(Hazardous Substances Data)

Upstream product

• 534-22-5 2-methylfuran 
• 108-31-6 maleic anhydride 
• 54384-23-5 (+/-)-1-methyl-7-oxa-norbornane-2endo,3endo-dicarboxylic acid 
• 941-63-9 exo-4-methyl-7-oxanicyclo[2.2.1]-2-heptene-5,6-dicarboxylic acid anhydride 
• 941-63-9 1-methyl-7-oxabicyclo<2.2.1>heptene-exo-2,3-dicarboxylic anhydride 

Downstream Products

• 2211-84-9 7-methyl-3H-isobenzofuran-1-one 
• 2211-83-8 4-methyl-3H-isobenzofuran-1-one 
• 4792-30-7 3-methylphthalic acid anhydride 
• 118-90-1 ortho-methylbenzoic acid 
• 23939-61-9 3-methylcyclohexene-1,2-dicarboxylic acid anhydride 
• 99-04-7 m-Toluic acid 
• 108-88-3 toluene 
• 54384-23-5 (+/-)-1-methyl-7-oxa-norbornane-2endo,3exo-dicarboxylic acid 
• 6624-08-4 exo-cis-1-Methyl-7-oxa-bicyclo<2.2.1>heptan-dicarbonsaeure-2,3-imid 
• 6624-08-4 3-Methyl-3,6-endoxo-hexahydrophthalsaeureimid 
• 54384-23-5 1-methyl-7-oxa-bicyclo{2.2.1}heptane-2-exo,3-cis-dicarboxylic acid 

Relevant articles and documents

IMPROVED PROCESS FOR THE PREPARATION OF A BENZENE COMPOUND

A benzene compound is prepared in a process, which comprises (i) reacting a furan compound of formula (I): wherein R1 and R2 are the same or different and independently selected from the group consisting of hydrogen, alkyl, aralkyl, -CHO, -CH2OR3, -CH(OR4 )(OR5), -COOR6, wherein R3, R4 and R5 are the same or different and are independently selected from the group consisting of hydrogen, alkyl, aryl, alkaryl, aralkyl, alkylcarbonyl and arylcarbonyl, or wherein R4 and R5 together form an alkylene group, and wherein R6 is selected from the group consisting of hydrogen, alkyl and aryl, with an olefin of the formula (II): R7-CH=CH-R8; wherein R7 and R8 are the same or different and are independently selected from the group consisting of hydrogen, sulfonate, -CN, -CHO, and -COOR9, wherein R9 is selected from the group consisting of hydrogen, and an alkyl group, or R7 and R8 together form a –C(O)-O-(O)C- group or a –C(O)-NR10-C(O)- group, wherein R10 represents hydrogen, an aliphatic or an aromatic group, to produce an unsaturated bicyclic ether having an unsaturated carbon-carbon bond; (ii) hydrogenating the unsaturated carbon-carbon bond in the unsaturated bicyclic ether to produce a saturated bicyclic ether; and (iii) dehydrating and aromatizing the saturated bicyclic ether to produce the benzene compound.

Total synthesis of neo-tanshinlactones through a cascade benzannulation-lactonization as the key step

The cascade annulation-lactonization of phthalides with α-carboxyfurylacrylates in the presence of lithium hexamethyldisilazide (LiHMDS) provides both convergent and semiconvergent regioselective syntheses of neo-tanshinlactones in moderate yields. This methodology also offers an avenue for the direct syntheses of hitherto unreported 6-alkoxycarbonyl-substituted neo-tanshinlactones and their heterocyclic analogues. A new synthesis of 4-alkyl phthalides was developed on the basis of a combination of a Duff reaction and Fuerstner cross-coupling. The cascade benzannulation-lactonization of phthalides with α-carboxyfurylacrylates was employed as the key reaction for the concise synthesis of neo-tanshinlactone. Copyright