6345-64-8Relevant articles and documents
MATRIX METALLOPROTEINASE (MMP) INHIBITORS AND METHODS OF USE THEREOF
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Paragraph 0224-0225, (2021/05/21)
Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.
Thieme Chemistry Journals Awardees - Where Are They Now?Molybdenum(V)-Mediated Synthesis of Nonsymmetric Diaryl and Aryl Alkyl Chalcogenides
Franzmann, Peter,Beil, Sebastian B.,Winterscheid, Peter M.,Schollmeyer, Dieter,Waldvogel, Siegfried R.
supporting information, p. 957 - 961 (2017/05/05)
Oxidative chalcogenation reaction using molybdenum(V) reagents provides fast access to a wide range of nonsymmetric aryl sulfides and selenides. The established protocol is tolerated by a variety of labile functions, protecting groups, and aromatic heterocycles. In particular, when labile moieties are present, the use of molybdenum(V) reagents provides superior yields compared to other oxidants.
Metal Organic Framework 199- Catalyzed Domino Sulfur-Coupling and Transfer Reactions: The Direct Synthesis of Symmetric Diaryl Disulfides from Aryl Halides
Soleiman-Beigi, Mohammad,Mohammadi, Fariba
, p. 1497 - 1504 (2016/07/30)
Abstract: A highly porous metal–organic framework Cu3 BTC2 (copper(II)-benzene-1,3,5-tricarboxylate) that known as MOF-199 was synthesized, and characterized by common methods including, FT-IR, XRD, EDX, SEM and then used as an efficient and recyclable catalyst for the direct synthesis of symmetric organic disulfides. A variety of symmetric diaryl disulfides with high chemoselectivity can be obtained by domino reaction of aryl halides (and tosylates) and potassium 5-methyl-1,3,4-oxadiazole-2- thiolate, as the base and sulfur-transfer reagent, in the presence of MOF-199. Graphical Abstract: [Figure not available: see fulltext.]