63459-07-4Relevant academic research and scientific papers
Electro-Mechanochemical Atom Transfer Radical Cyclizations using Piezoelectric BaTiO3
Bolm, Carsten,Hernández, José G.,Schumacher, Christian
, p. 16357 - 16360 (2020)
The formation and regeneration of active CuI species is a fundamental mechanistic step in copper-catalyzed atom transfer radical cyclizations (ATRC). Typically, the presence of the catalytically active CuI species in the reaction mix
Novel transformation of α,β-unsaturated aldehydes and ketones into γ-amino alcohols or 1,3-oxazines via a 4 or 5 step, one-pot sequence
Calow, Adam D. J.,Batsanov, Andrei S.,Fernández, Elena,Solé, Cristina,Whiting, Andrew
, p. 11401 - 11403 (2013/01/15)
An efficient, 4-step, one-pot, highly stereoselective route to γ-amino alcohols has been developed via an in situ α,β- unsaturated imine formation, β-boration, reduction (CN) and oxidation (C-B) sequence and especially for certain water-soluble γ-amino alcohols, a further step can be added to directly access the corresponding 1,3-oxazine derivatives.
Asymmetric synthesis of Sedum alkaloids via lithium amide conjugate addition
Davies, Stephen G.,Fletcher, Ai M.,Roberts, Paul M.,Smith, Andrew D.
supporting information; experimental part, p. 10192 - 10213 (2010/02/28)
Conjugate addition of lithium (R)-N-allyl-N-(α-methylbenzyl)amide or lithium (R)-N-but-3-enyl-N-(α-methylbenzyl)amide to an alkyl hexa-2,4-dienoate or alkyl hepta-2,6-dienoate, followed by ring-closing metathesis of the olefin functionalities within the resultant β-amino ester, generates a range of diastereoisomerically pure azacycles in good yield. These homochiral templates are readily transformed to a range of piperidine alkaloids of the Sedum family, and the corresponding five-, seven- and eight-membered ring homologues.
