634604-04-9

Upstream product

• 624-31-7 4-tolyl iodide 
• 536-74-3 phenylacetylene 
• 5720-05-8 4-methylphenylboronic acid 
• 106-49-0 p-toluidine 
• 98-86-2 acetophenone 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 2101-86-2 p-methylazidobenzene 
• 122-78-1 phenylacetaldehyde 
• 637-44-5 phenylpropyolic acid 
• 106-38-7 para-bromotoluene 
• 532-27-4 1-chloroacetophenone 
• 71094-28-5 N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 4545-21-5 acetophenone p-toluenesulfonylhydrazone 

Downstream Products

• 1345842-04-7 4-(2-chlorophenyl)-1-(4-methylphenyl)-1,2,3-triazole 
• 227959-99-1 methyl 1-(4-methylphenyl)-1H-1,2,3-triazole-4-carboxylate 

Relevant academic research and scientific papers

Coinage metal metallacycles involving a fluorinated 3,5-diarylpyrazolate

Copper(i) and silver(i) pyrazolate complexes {[3,5-(3,5-(CF3)2Ph)2Pz]Cu}3and {[3,5-(3,5-(CF3)2Ph)2Pz]Ag}3have been synthesized using the fluorinated 3,5-(diaryl)pyrazole 3,5-(3,5-(CF3)2Ph)2PzH and copper(i) oxide and silver(i) oxide, respectively. The gold(i) analog was obtained from a reaction between Au(THT)Cl and [3,5-(3,5-(CF3)2Ph)2Pz]H/NaH. The X-ray crystal structures show that the coinage metal complexes {[3,5-(3,5-(CF3)2Ph)2Pz]M}3(M = Cu, Ag, Au) are trinuclear in the solid state. They feature distorted nine-membered M3N6metallacyclic cores. The M-N distances follow Cu 3)2Ph)2PzH forms hydrogen bonded trimers in the solid state that are further organized by π-stacking between aryl rings. Solid samples of {[3,5-(3,5-(CF3)2Ph)2Pz]M}3display blue photoluminescence. The copper complex {[3,5-(3,5-(CF3)2Ph)2Pz]Cu}3is an excellent catalyst for mediating azide-alkyne cycloaddition chemistry.

Half Sandwich Electron Deficient N,N′,N′′-Triarylguanidinatoruthenium(II) Complexes: Syntheses, Reactivity Studies, and Structural Aspects

Three symmetrical N,N′,N′′-triarylguanidinatoruthenium(II) complexes, [(η6-p-cymene)RuCl{κ2(N,N′)((ArN)2C-N(H)Ar)}] (Ar = 2-(CF3)C6H4 (1), 4-(CF3)C6H4 (2) a

Terminal and internal alkyne complexes and azide-alkyne cycloaddition chemistry of copper(I) supported by a fluorinated bis(pyrazolyl)borate

Copper plays an important role in alkyne coordination chemistry and transformations. This report describes the isolation and full characterization of a thermally stable, copper(I) acetylene complex using a highly fluorinated bis(pyrazolyl)borate ligand su

Immobilization of vitamin B1 on the magnetic dialdehyde starch as an efficient carbene-type support for the copper complexation and its catalytic activity examination

Since the starch biopolymer is an available and inexpensive matrix with modifiable functionality and stabilization capability for metal ions, in this report, we oxidized it to dialdehyde form for the further functionalization with vitamin B1 as a green σ-donor and π-acceptor carbene type ligand. Immobilization of vitamin B1 on this biopolymer was done through imine bond formation between NH2 groups of aminopyrimidine segment of vitamin B1 and aldehyde functional groups of starch oxide. Thiazolium heterocycle part in this biomolecule provided a carbene type precursor for the metal complexation. After the magnetization process by using of Fe3O4 nanoparticles that lead to quick and facile magnetic separation and metal catalyst recycling, copper ions immobilized on the magnetic support (5.9 wt% Cu, 0.93 mmol/g). The prepared copper N-heterocyclic carbene complex (Fe3O4@DAS@VB1@CuCl nanocomposite) was characterized by FT-IR, SEM, EDX, XRD, VSM, TGA and ICP-OES analysis and then its catalytic activity investigated in azidonation of arylboronic acids and also one-pot coupling reaction of the synthesized aryl azides with phenylacetylene. 1,4-Diaryl 1,2,3-triazoles were obtained in excellent yields (≥90%) at proper reaction times (30–200 min). The magnetic catalyst was recovered by a magnetic field and reused in azidation reaction up to 7 cycle.

A sustainable approach for efficient one-pot synthesis of 1-aryl 1,2,3-triazoles using copper iodide supported on 3-thionicotinyl-urea-modified magnetic nanoparticles in DES

An efficient and retrievable copper(I) catalyst was synthesized by immobilizing of copper iodide on 3-thionicotinyl-urea-modified magnetic nanoparticles and characterized using a variety of analysis techniques. The catalytic activity of these nanoparticle

Catalytic performance of Cu(II)-supported graphene quantum dots modified NiFe2O4 as a proficient nano-catalyst in the synthesis of 1,2,3-triazoles

Abstract: NiFe2O4 nanoparticles are modified by graphene quantum dots (GQDs) and utilized to stabilize the Cu(II) nanoparticles as a novel magnetically retrievable catalytic system (Cu(II)/GQDs/NiFe2O4) for gree

Palladium-catalyzed selective ortho C–H alkoxylation at 4-aryl of 1, 4-disubstituted 1, 2, 3-triazoles

The ortho- C–H bonds at C(4)-aryl of 1, 4-disubstituted 1, 2, 3-triazoles were regioselectively alkoxylated in good to excellent yields with under the directing of the triazole ring. Some products were found to exhibit strong antifungal capacity to fight against root-rot disease of Panax notoginseng by testing the minimum inhibitory concentration (MIC).

Water as a solvent for Ru-catalyzed click reaction: Highly efficient recyclable catalytic system for triazolocoumarins synthesis

A new family of Ru (III) complexes has been synthesized, characterized and their catalytic performance has been tested for alkyne–azide cycloaddition (AAC) in water under ultrasonic irradiation conditions. These complexes are found to be effective heterog

Synthesis, characterization, and investigation of catalytic activity of copper(II) porphyrin graphene oxide for azide–alkyne cycloaddition

Abstract: A covalently cross-linked graphene oxide (GO) catalyst was prepared by a cross-linking process using nucleophilic reaction of copper(II)‐coordinated 5,10,15,20-tetrakis(aminophenyl)porphyrin (CuPPh) with carboxyl groups at the edges of GO (GO–CuPPh). The structure of the catalyst was characterized using different techniques such as Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive x-ray spectroscopy (EDS), thermogravimetric analysis (TGA), and inductively coupled plasma (ICP) spectroscopy. All analyses confirmed successful covalent immobilization of CuPPh on GO. The activity of the catalyst was then studied for synthesis of 1,4-disubstituted 1,2,3-triazoles derivatives by reaction of various aryl azides and different terminal alkynes in mild reaction condition with good to excellent yield. Graphical abstract: [Figure not available: see fulltext.].

Ag2CO3-catalyzed cycloaddition of organic azides onto terminal alkynes: A green and sustainable protocol accelerated by aqueous micelles of CPyCl

Using catalytic amount of Ag2CO3 a simple, efficient and copper free green protocol has been developed to synthesize 1,4-disubstituted 1,2,3-triazoles regioselectively. Here, the cationic surfactant, cetylpyridinium chloride (CPyCl) in water provides a micellar media and accelerates the subsequent Ag(I)-catalysed azide-alkyne cycloaddition (AgAAC) reaction by increasing the concentration of reactants in the micellar pseudophase. Our method is found to be environmentally friendly from E-factor measurement. The surfactant, CPyCl is found to be nontoxic.