63494-69-9

Upstream product

• 6623-41-2 2-amino-4,5-dimethylphenol 
• 108-24-7 acetic anhydride 
• 95-65-8 3,4-Dimethylphenol 
• 123765-70-8 N-(2-iodo-4,5-dimethylphenyl)acetamide 
• 75-36-5 acetyl chloride 
• 70637-61-5 2-acetamido-4,5-dimethylphenyl acetate 
• 7732-18-5 water 

Downstream Products

• 78022-17-0 5,6-Dimethyl-2-(4-(2-cyanostyryl)styryl)benzoxazole 
• 24664-70-8 4-[2-(5,6-dimethyl-benzooxazol-2-yl)-vinyl]-benzonitrile 
• 73916-17-3 {4-[(E)-2-(5,6-Dimethyl-benzooxazol-2-yl)-vinyl]-phenyl}-dimethyl-amine 
• 24664-71-9 2-[(E)-2-(4-Methoxy-phenyl)-vinyl]-5,6-dimethyl-benzooxazole 
• 73916-15-1 4-[(E)-2-(5,6-Dimethyl-benzooxazol-2-yl)-vinyl]-phenol 
• 57019-56-4 5,6-Dimethyl-2-((E)-styryl)-benzooxazole 
• 73916-16-2 2-[(E)-2-(4-Chloro-phenyl)-vinyl]-5,6-dimethyl-benzooxazole 
• 73916-18-4 5,6-Dimethyl-2-[(E)-2-(4-nitro-phenyl)-vinyl]-benzooxazole 
• 19219-98-8 2,5,6-trimethylbenzo[d]oxazole 

Relevant academic research and scientific papers

Cp?Rh(III)/Bicyclic Olefin Cocatalyzed C-H Bond Amidation by Intramolecular Amide Transfer

A bicyclic olefin was discovered as a cocatalyst in a Cp?Rh(III)-catalyzed C-H bond amidation proceeding by an intramolecular amide transfer in N-phenoxyacetamide derivatives. Combining experimental and theoretical studies, we propose that the olefin promotes a Rh(III) intermediate to undergo oxidative addition into the O-N bond to form a Rh(V) nitrenoid species and subsequently direct the nitrenoid to add to the ortho position. The amide directing group plays a dual role as a cleavable coordinating moiety as well as an essential coupling partner for the C-H amidation. This methodology was successfully applied to the late-stage diversification of natural products and a marketed drug under mild conditions.

Divergent reactivities of o-haloanilides with CuO nanoparticles in water: A green synthesis of benzoxazoles and o-hydroxyanilides

In the present study, three divergent reaction paths emerged when o-haloanilides were subjected to CuO nanoparticles in water. o-Halo (I, Br) phenylbenzamides in the presence of CuO nanoparticles and Cs2CO 3 in water at 100 °C provided o-hydroxyphenyl benzamides as the major product. However, a complete change in selectivity was observed in the presence of an organic base/ligand (TMEDA), giving 2-arylbenzoxazole as the exclusive product. The above selectivities were not clearly distinct when the corresponding alkylamides were treated either in the presence or absence of the ligand. A number of o-halophenyl alkylamides provided either exclusively o-dehalogenated products or a mixture of o-dehalogenated and o-hydroxylated products, but none gave 2-alkylbenzoxazoles. In addition to the above selectivities, the use of an environmentally friendly solvent (water) and base, and the recyclability of the catalyst make this procedure a benign alternative to the existing methods for the synthesis of these molecules, viz. o-hydroxybenzamides and o-arylbenzoxazoles.

l , l , 3-TRI0X0-l , 2 , 5-THIADIAZ0LIDINES AND THEIR USE AS PTP-ASES INHIBITORS

Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be employed as inhibitors of other e