63588-96-5Relevant academic research and scientific papers
Enantio- And Diastereoselective Construction of Contiguous Tetrasubstituted Chiral Carbons in Organocatalytic Oxadecalin Synthesis
Wada, Yuuki,Murata, Ryuichi,Fujii, Yuki,Asano, Keisuke,Matsubara, Seijiro
supporting information, p. 4710 - 4715 (2020/07/06)
The organocatalytic enantio- and diastereoselective cycloetherification of 1,3-cyclohexanedione-bearing enones involving the in situ generation of chiral cyanohydrins was developed. This transformation offers the first catalytic asymmetric approach to oxa
Asymmetric Synthesis of Carbocyclic Propellanes
Schneider, Lisa M.,Schmiedel, Volker M.,Pecchioli, Tommaso,Lentz, Dieter,Merten, Christian,Christmann, Mathias
supporting information, p. 2310 - 2313 (2017/05/12)
A modular synthesis of functionalized carbocyclic propellanes was developed. Formation of the first of two quaternary bridgehead centers has been achieved by desymmetrization of prostereogenic ketones by either Hajos-Parrish-Eder-Sauer-Wiechert-type processes or Werner’s catalytic asymmetric Wittig reaction. The obtained bicyclic enones were subjected to conjugate additions upon which the remaining ring was formed by olefin metathesis. All bridges are amenable to further derivatization, which renders those compounds useful as central units in fragment-based drug discovery or as ligand scaffolds.
Generation of Azomethine Ylides via the Desilylation Reaction of Immonium Salts
Padwa, Albert,Haffmanns, Gunter,Tomas, Miguel
, p. 3314 - 3322 (2007/10/02)
Generation of intermediates having azomethine ylide reactivity was achieved by the reaction of several ethanol or thioimidate derivatives with methyl iodide followed by treatment of the resulting imine with (trimethylsilyl)methyl triflate.Desilylation of
