63644-86-0Relevant academic research and scientific papers
ROR NUCLEAR RECEPTOR MODULATORS
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Page/Page column 76; 77, (2016/12/26)
The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.
A General Synthesis of 5-Arylnicotinates
Thompson, Wayne J.,Gaudino, John
, p. 5237 - 5243 (2007/10/02)
Arylboronic acids have been found to couple efficiently with 5-bromonicotinates to yield 5-arylnicotinates.The reaction is considerably more sensitive to steric inhibition in the arylboronic acid component than in the pyridyl bromide 4.The dianion salt of the boronic acid is implicated as the reactive intermediate responsible for the facile coupling reaction.Pure arylboronic acids are best prepared by using triisopropyl borate as the transmetalating agent.
