47672-25-3

Usage

Uses

Used in Pharmaceutical Research:
L-Phenylalanine, N-(triphenylmethyl)is used as a research tool for studying biological processes and designing new drugs. Its unique structure allows researchers to investigate the interactions of L-phenylalanine with various biological systems and develop novel therapeutic agents.
Used in Drug Design:
As a derivative of L-phenylalanine, L-Phenylalanine, N-(triphenylmethyl)is utilized in drug design to create new pharmaceutical compounds. Its distinct chemical properties enable the development of innovative drugs with potential applications in treating various diseases and conditions.

Upstream product

• 150-30-1 Phenylalanine 
• 76-83-5 trityl chloride 
• 63-91-2 L-phenylalanine 
• 5269-44-3 O-(Trimethylsilyl)phenylalanine 

Downstream Products

• 73994-87-3 (S)-benzyl 2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanoate hydrochloride 
• 112839-75-5 N-(triphenylmethyl)-L-phenylthioalanine S-2-pyridinyl ester 
• 92466-16-5 N-trityl-phenylalanine succinimide ester 
• 115731-96-9 Trt-Phe-ODpm 
• 92466-04-1 Trt-Phe-Leu-OBzl 
• 92466-03-0 N-trityl-phenylalanine-glycine benzyl ester 
• 100841-19-8 (S)-(-)-3-Phenyl-2-triphenylmethylamino-1-propanol 
• 131941-55-4 Trt-Phe-ODhbt 
• 63649-15-0 L-phenylalanyl-L-leucine benzyl ester 
• 92176-58-4 Trityl-L-phenylalanylbenzotriazolylester 
• 93266-75-2 C₃₄H₂₈N₄O₂ 
• 210580-12-4 3-oxo-5-phenyl-4S-(tritylamino)pentanoic acid allyl ester 
• 1072014-08-4 C₄₅H₄₆N₂O₅ 
• 1072014-07-3 C₄₅H₄₆N₂O₅ 

Relevant academic research and scientific papers

Hydrogen-Borrowing Alkylation of 1,2-Amino Alcohols in the Synthesis of Enantioenriched γ-Aminobutyric Acids

For the first time we have been able to employ enantiopure 1,2-amino alcohols derived from abundant amino acids in C?C bond-forming hydrogen-borrowing alkylation reactions. These reactions are facilitated by the use of the aryl ketone Ph*COMe. Racemisation of the amine stereocentre during alkylation can be prevented by the use of sub-stoichiometric base and protection of the nitrogen with a sterically hindered triphenylmethane (trityl) or benzyl group. The Ph* and trityl groups are readily cleaved in one pot to give γ-aminobutyric acid (GABA) products as their HCl salts without further purification. Both steps may be performed in sequence without isolation of the hydrogen-borrowing intermediate, removing the need for column chromatography.

Highly stereoselective syntheses of syn- and anti-1,2-amino alcohols

The reduction of N-protected amino ketones can be carried stereoselectively to produce either the syn- or anti-amino alcohol diastereomer. Carbamate-protected amino ketones can be reduced predictably and selectively to anti-amino alcohols with LiAlH(O-t-Bu)3 in ethanol at -78°C. N-Trityl-protected amino ketones can be reduced selectively to syn-amino alcohols with LiAlH(O-t-Bu)3 in THF at -5°C.

Efficient Synthesis of N-Triphenylmethyl α-Amino Acids

A new one-pot synthesis of N-triphenylmethyl(trityl) α-amino acids 3 via their trityl ester 2 has been developed.

Efficient "One-Pot" Synthesis of N-Trityl Amino Acids

A sequential procedure has been developed whereby neutral amino acids 1 were tritylated via their corresponding trimethylsilyl esters 2 to afford, after mild hydrolysis, N-trityl amino acids 3 in high yields and purity.Hydroxy amino acids 4 were preferent