47672-25-3

Usage

Uses

Used in Pharmaceutical Research:
L-Phenylalanine, N-(triphenylmethyl)is used as a research tool for studying biological processes and designing new drugs. Its unique structure allows researchers to investigate the interactions of L-phenylalanine with various biological systems and develop novel therapeutic agents.
Used in Drug Design:
As a derivative of L-phenylalanine, L-Phenylalanine, N-(triphenylmethyl)is utilized in drug design to create new pharmaceutical compounds. Its distinct chemical properties enable the development of innovative drugs with potential applications in treating various diseases and conditions.

Upstream product

• 63-91-2 L-phenylalanine 
• 76-83-5 trityl chloride 
• 150-30-1 Phenylalanine 
• 5269-44-3 O-(Trimethylsilyl)phenylalanine 

Downstream Products

• 92176-58-4 Trityl-L-phenylalanylbenzotriazolylester 
• 93266-75-2 C₃₄H₂₈N₄O₂ 
• 222618-93-1 N-trityl-L-phenylalanine-N-carboxyanhydride 
• 214344-15-7 (L)-Trt-Phe-F 
• 210580-12-4 3-oxo-5-phenyl-4S-(tritylamino)pentanoic acid allyl ester 
• 387866-80-0 1-phenyl-2S-(tritylamino)undecan-3-one 
• 1026285-44-8 (2S,3S)-1-Phenyl-2-(trityl-amino)-undecan-3-ol 
• 5879-43-6 (+/-)-N-Trityl-phenylalanin-<2-methylmercaptoaethylester> 
• 112839-75-5 N-(triphenylmethyl)-L-phenylthioalanine S-2-pyridinyl ester 
• 73994-87-3 (S)-benzyl 2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanoate hydrochloride 
• 872719-69-2 Ac-[D-Tyr⁴⁶,D-Trp⁴⁷,Thr⁴⁹,azaGly⁵¹,Arg(Me)⁵³]metastin(46-54) 
• 872718-97-3 [D-Tyr⁴⁶,D-Pya⁽⁴⁾⁴⁷,Ala⁴⁸,azaGly⁵¹,Arg(Me)⁵³,Trp⁵⁴]metastin(46-54) 
• 872719-29-4 [D-Tyr⁴⁶,D-Pya⁽⁴⁾⁴⁷,Hyp⁴⁹,azaGly⁵¹,Arg(Me)⁵³,Trp⁵⁴]metastin(46-54) 
• 872719-30-7 [D-Tyr⁴⁶,D-Pya⁽⁴⁾⁴⁷,Pro⁴⁹,azaGly⁵¹,Arg(Me)⁵³,Trp⁵⁴]metastin(46-54) 

Relevant academic research and scientific papers

Hydrogen-Borrowing Alkylation of 1,2-Amino Alcohols in the Synthesis of Enantioenriched γ-Aminobutyric Acids

For the first time we have been able to employ enantiopure 1,2-amino alcohols derived from abundant amino acids in C?C bond-forming hydrogen-borrowing alkylation reactions. These reactions are facilitated by the use of the aryl ketone Ph*COMe. Racemisation of the amine stereocentre during alkylation can be prevented by the use of sub-stoichiometric base and protection of the nitrogen with a sterically hindered triphenylmethane (trityl) or benzyl group. The Ph* and trityl groups are readily cleaved in one pot to give γ-aminobutyric acid (GABA) products as their HCl salts without further purification. Both steps may be performed in sequence without isolation of the hydrogen-borrowing intermediate, removing the need for column chromatography.

Highly stereoselective syntheses of syn- and anti-1,2-amino alcohols

The reduction of N-protected amino ketones can be carried stereoselectively to produce either the syn- or anti-amino alcohol diastereomer. Carbamate-protected amino ketones can be reduced predictably and selectively to anti-amino alcohols with LiAlH(O-t-Bu)3 in ethanol at -78°C. N-Trityl-protected amino ketones can be reduced selectively to syn-amino alcohols with LiAlH(O-t-Bu)3 in THF at -5°C.

Efficient Synthesis of N-Triphenylmethyl α-Amino Acids

A new one-pot synthesis of N-triphenylmethyl(trityl) α-amino acids 3 via their trityl ester 2 has been developed.

Efficient "One-Pot" Synthesis of N-Trityl Amino Acids

A sequential procedure has been developed whereby neutral amino acids 1 were tritylated via their corresponding trimethylsilyl esters 2 to afford, after mild hydrolysis, N-trityl amino acids 3 in high yields and purity.Hydroxy amino acids 4 were preferent