636589-28-1Relevant articles and documents
Synthesis and analysis of novel glycerolipids for the treatment of metabolic syndrome
Jorgensen, Michael R.,Bhurruth-Alcor, Yushma,R?st, Therese,Bohov, Pavol,Müller, Melanie,Guisado, Cristina,Kostarelos, Kostas,Dyr?y, Endre,Berge, Rolf K.,Miller, Andrew D.,Skorve, Jon
, p. 1172 - 1179 (2009)
Tetradecylthioacetic acid (TTA) 1 is a peroxisome proliferator-activated receptor (PPAR) agonist found to improve insulin sensitivity, lower blood lipid levels, enhance fatty acid oxidation, and promote anti-inflammation in vivo. In an attempt to enhance these properties, two key thioether fatty acid (Thefa) lipids, ditetradecylthioacetyl phosphatidylcholine 2 and tritetradecylthioacetyl glycerol 3, are synthesized and administered po to male Wistar rats at two different doses to study and compare metabolic outcomes relative to the administration of 1 alone after 6 days. Liposomal formulations of 1 and 2 are also prepared to evaluate acute metabolic responses (at 3 h) post iv injection. Across all metrics measured, 1-induced responses post po administration are in line with previous data. Responses induced from 3 are mostly equivalent to 1-induced responses. By contrast, 2-induced responses almost always outperform those of 1 and 3. Therefore, 2 may represent a new lead for the treatment of metabolic syndrome.
