63660-82-2Relevant academic research and scientific papers
The Synthesis of Quinazolinones from Olefins, CO, and Amines over a Heterogeneous Ru-clusters/Ceria Catalyst
An, Jinghua,Wang, Yehong,Zhang, Zhixin,Zhao, Zhitong,Zhang, Jian,Wang, Feng
supporting information, p. 12308 - 12312 (2018/09/06)
Quinazolinones, an important class of heterocyclic compounds, have been widely used in pharmaceuticals because of their biological activity. However, the efficient and economical synthesis of quinazolinones has remained a challenge. A novel synthetic approach has now been developed to produce quinazolinones from olefins, CO, and amines over heterogeneous Ru-clusters/ceria catalyst in the absence of acids, bases, and oxidants. Furthermore, H2O is generated as the only by-product. A series of quinazolinones with aromatic or non-aromatic substituents can be obtained in yields of up to 99 %. The Ru-clusters/ceria can be reused at least four times. The analysis of the E-factor (environmental impact factor) for the synthesis of 2-ethyl quinazolinone suggests that this system is more environmentally friendly than other processes reported previously.
Quinazolinone compound preparation method
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Paragraph 0096-0098, (2018/09/28)
The present invention relates to a quinazolinone compound preparation method, wherein a quinazolinone-based compound is prepared by using 2-aminobenzamide, olefin and carbon monoxide as reaction substrates and using tetrahydrofuran as a solvent under the catalysis effect of a ruthenium loaded metal oxide. The reaction process comprises: adding tetrahydrofuran, 2-aminobenzamide, olefin and a catalyst into a pressure container, inflating with carbon monoxide, sealing, stirring, and carrying out a reaction for not less than 0.5 h at a reaction temperature of not lower than 120 DEG C, wherein thecatalyst is easily separated from the reaction system after the reaction, and can be recycled multiple times, and the yield of the quinazolinone-based compound is up to 100%.
Intramolecular Reactions of N-Nitrenes: Oxidation of 3-Amino-2-(arylalkyl)quinazolin-4(3H)-ones
Atkinson, Robert S.,Malpass, John R.,Woodthorpe, Katherine L.
, p. 2407 - 2412 (2007/10/02)
Oxidation of the title compounds yields N-nitrenes which react intramolecularly with methoxy-substituted aryl rings.The particular substitution pattern in the aryl rings which is required for effective trapping of the nitrenes is in accord with an electro
Intramolecular Reactions of N-Nitrenes: Oxidation of 3-Amino-2-(arylalkyl)quinazolones
Atkinson, Robert S.,Malpass, John R.,Woodthorpe, Katherine L.
, p. 160 - 162 (2007/10/02)
Oxidation of the title compounds yields N-nitrenes which react intramolecularly with electron-rich aryl groups via 7-membered transition states; substituent effects are in accord with an electrophilic aromatic substitution rather than concerted addition.
