637-54-7Relevant academic research and scientific papers
Nano-Magnetic Sulfonic Acid Catalyzed Facile Synthesis of Diverse Amide Derivatives
Kothandapani, Jagatheeswaran,Ganesan, Asaithampi,Ganesan, Subramaniapillai Selva
, p. 685 - 692 (2017/01/25)
The excellent surface catalytic potential of Fe3O4-OSO3H is utilized in the synthesis of symmetrically and unsymmetrically substituted urea derivatives via transamidation reactions. The scope of the surface catalysis is further extended in transamidation reactions of cyclic and acyclic amide derivatives, and in the amidation of fatty acids. In both transamidation and amidation reactions, the catalyst is reusable up to five times without significant loss in its activity.
A METHOD OF TREATING PERIPHERAL INFLAMMATORY DISEASE
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Paragraph 0078-0084; 0135-0136, (2016/12/01)
An active for use in the treatment or inhibition of an inflammatory disease associated with over-activation of Toll-like Receptor 4 (TLR4), Toll-like Receptor 2 (TLR2) and Myeloid differentiating protein 88 (Myd88) adaptor-like protein (Mal) while maintaining a subject's ability to respond normally to a pathogen, in which the active is an oleamide or a derivative thereof.
Cleavage of C-N bonds in guanidine derivatives and its relevance to efficient C-N bonds formation
Chang, Denghu,Zhu, Dan,Zou, Peng,Shi, Lei
, p. 1684 - 1693 (2015/03/30)
Efficient nonenzymatic decomposition of guanidine derivatives with high structural and functional diversity into anilide products is achieved in the presence of PdII/Cu(II) carboxylates/CO, relying on a dual C-N bonds cleavage strategy. In this decomposition process, the cooperative action of PdII species, Cu(II) carboxylates, and CO provides not only the N-acylating agents but also an initiator to trigger this C-N bonds cleavage sequence. The current results indicate that PdII/Cu(II) carboxylates/CO system provides a convenient and practical method for highly selective cleavage of unreactive C-N single bonds.
Nano sulfated titania as solid acid catalyst in direct synthesis of fatty acid amides
Hosseini-Sarvari, Mona,Sodagar, Esmat,Doroodmand, Mohammad Mahdi
supporting information; experimental part, p. 2853 - 2859 (2011/05/17)
Nanosized sulfated titania was prepared by a sol-gel hydrothermal process. X-ray diffraction (XRD), transmission electron, and scanning electron micrographs (TEM and SEM), FT-IR specific surface area, and BET N2 adsorption were employed to characterize the properties of the synthesized sulfated TiO2. The results indicate that both anatase and rutile TiO2 are obtainable. This prepared sulfated titania showed high catalytic activity in direct amidation of fatty acids as well as benzoic acids with various amines under solvent-free conditions.
Total synthesis of monocyclic pyrimidinium betaines with fatty alkyl chains
Malki, Fatiha,Touati, Abdelkader,Rahal, Said,Moulay, Saad
scheme or table, p. 961 - 967 (2011/12/21)
Seven betaines were prepared by condensation of N,N'-diphenylamidines with malonic acid derivatives. The amidines were made via a multistep synthesis, starting from their corresponding fatty acids. Malonyl chloride and dipentachlorophenyl phenylmalonate, two derivatives of malonic acid, were obtained from malonic acid and benzyl chloride, respectively. Most of the products were characterized by IR, UV, 1H and 13C NMR. Biological assays of the synthesized betaines revealed their good antibacterial and antifungal activities against the Pseudomonas aeruginosa, Bacillus subtilis and Mucor ramannianus and an activity against Candida albicans.
ZnO nanofluid as a structure base catalyst for chemoselective amidation of aliphatic carboxylic acids
Tamaddon, Fatemeh,Aboee, Fatemeh,Nasiri, Alireza
experimental part, p. 194 - 197 (2012/02/04)
ZnO nanofluids were synthesized and utilized as a new reaction media in the preparation of amides via direct amidation of aliphatic carboxylic acids with primary amines under solvent-free conditions. High yields and good selectivity are achieved with this psudo-homogeneous catalyst, while the recovered nanoZnO was reusable.
A simple and convenient procedure for the conversion of esters to secondary amides
Ranu, Brindaban C.,Dutta, Pinak
, p. 297 - 301 (2007/10/03)
An improved procedure has been developed for the direct conversion of carboxylic esters to secondary amides by simple treatment with primary amines in presence of indium triiodide.
N-Cyanazoles in Synthesis of Amides of Carboxylic Acids
Purygin,Pan'kov
, p. 871 - 873 (2007/10/03)
The reaction of carboxylic acids with 1-cyanimidazole, 1-cyanobenzimidazole, and 1-cyano-1,2,4-triazole leads to the formation of 1-acylazoles used in situ in synthesis of anilides of the corresponding carboxylic acids.
Synthesis of Aniline Derivatives with Potential Toxicological Implications to the Spanish Toxic Oil Syndrome
Ferrer, Marta,Galceran, Montserrat,Sanchez-Baeza, Francisco,Casas, Josefina,Messeguer, Angel
, p. 507 - 512 (2007/10/02)
The synthesis of anilides 2 from several saturated and unsaturated fatty acids 1 required for toxicological studies related to the Spanish Toxic Oil Syndrome is reported.In addition, a simple procedure for the determination of the position of a carbon-carbon double bond of a fatty acid residue is described.This procedure involves epoxidation of the sample with 3,3-dimethyldioxirane followed by oxidative cleavage with periodic acid to yield the corresponding carbonyl derivatives which are easily identifiable by GC-MS analysis.Finally, the synthesis of anilino derivatives 5-8 formally derived from glycerol is also reported.For this purpose, a common precursor, i.e. 3-(phenylamino)propane-1,2-diol (4) is prepared, and convenient procedures for its chemoselective acylation at either the hydroxy or the amino group have been developed. Key Words: Toxic oil syndrome / Aniline / Fatty acids, synthesis of
Synthesis of a new saccharin derivative (BID-SPy) and its utilization as a condensing reagent in the preparation of dipeptides
Ahmed, A,Akhter, H
, p. 564 - 565 (2007/10/02)
A new saccharin derivative, thiopyridyl-benzisothiazole 1,1-dioxide (BID-SPy, 2), has been prepared by the reaction of BID-Cl (1) and 2-mercaptopyridine, and utilized as a coupling reagent in the synthesis of amides and N-protected dipeptides.
