6372-48-1Relevant articles and documents
Compound containing phosphine chiral center, organic transition metal complex and preparation method thereof
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Paragraph 0049-0053, (2021/07/10)
The invention provides a compound containing a phosphine chiral center, an organic transition metal complex and a preparation method thereof. The preparation method of the compound comprises the following steps: (1) reducing a secondary phosphine oxide 1 into a product secondary phosphine hydrogen 2 by using a reducing agent, wherein the reaction temperature is 20 to 100 DEG C, and the reaction time is 12 to 120 hours; and (2) adding alkyne and the secondary phosphine hydrogen prepared in the step (1) into an organic solvent by using a metal catalyst and a chiral ligand as catalysts to obtain the chiral phosphine compound. The synthesized chiral phosphine compound can be used as a ligand to directly react with transition metal salt to synthesize various organic transition metal complexes. According to the synthesis method disclosed by the invention, secondary phosphine oxide with good stability and low odor is used as a raw material, so that direct use of secondary phosphine with high toxicity and odor for reaction is avoided, and the chiral trivalent phosphine product and the derivative thereof are efficiently and selectively obtained.
Simple unprecedented conversion of phosphine oxides and sulfides to phosphine boranes using sodium borohydride
Rajendran, Kamalraj V.,Gilheany, Declan G.
, p. 817 - 819 (2012/02/03)
A variety of phosphine oxides and sulfides can be efficiently converted directly to the corresponding phosphine boranes using oxalyl chloride followed by sodium borohydride. Optically active P-stereogenic phosphine oxides can be converted stereospecifically to phosphine boranes with inversion of configuration by treatment with Meerwein's salt followed by sodium borohydride.
Reduction of phosphinites, phosphinates, and related species with DIBAL-H
Busacca, Carl A.,Bartholomeyzik, Teresa,Cheekoori, Sreedhar,Raju, Ravinder,Eriksson, Magnus,Kapadia, Suresh,Saha, Anjan,Zeng, Xingzhong,Senanayake, Chris H.
scheme or table, p. 287 - 291 (2009/07/01)
Diisobutylaluminium hydride has been found to be an excellent reducing agent for phosphinites, phosphinates, and chlorophosphines. By performing reductions in situ, direct synthesis of secondary phosphine boranes from Grignard reagents has been achieved without isolation or purification of any intermediates. Georg Thieme Verlag Stuttgart.
