637748-30-2Relevant articles and documents
Enantioselective Reaction between 2-(Cyanomethyl)azaarenes and N-Boc-amino Sulfones
Wang, Kezhou,Chen, Chao,Liu, Xihong,Li, Dan,Peng, Tianyu,Liu, Xin,Yang, Dongxu,Wang, Linqing
, p. 5260 - 5263 (2018)
A series of 2-(cyanomethyl)azaarenes containing benzothiazole or benzoxazole were designed and synthesized for asymmetric α-functionalization with N-Boc-amino sulfones. The Mannich adducts were obtained in high yields with good diastereo- and enantioselectivities. Aryl-substituted amino sulfones were tolerated under the current conditions, and the reaction can be performed on gram scale in good results.
