Organic Letters p. 5260 - 5263 (2018)
Update date:2022-07-29
Topics:
Wang, Kezhou
Chen, Chao
Liu, Xihong
Li, Dan
Peng, Tianyu
Liu, Xin
Yang, Dongxu
Wang, Linqing
A series of 2-(cyanomethyl)azaarenes containing benzothiazole or benzoxazole were designed and synthesized for asymmetric α-functionalization with N-Boc-amino sulfones. The Mannich adducts were obtained in high yields with good diastereo- and enantioselectivities. Aryl-substituted amino sulfones were tolerated under the current conditions, and the reaction can be performed on gram scale in good results.
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(2018)