6384-92-5 Usage
Chemical Properties
white to off-white crystalline powder
Uses
Different sources of media describe the Uses of 6384-92-5 differently. You can refer to the following data:
1. NMDA agonist
2. NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
Definition
ChEBI: An aspartic acid derivative having an N-methyl substituent and D-configuration.
General Description
N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.
Biological Activity
Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset? .
Biochem/physiol Actions
Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy.
references
[1] watkins jc, jane de. the glutamate story. br j pharmacol. 2006 jan;147 suppl 1:s100-8.[2] lafon-cazal m, pietri s, culcasi m, bockaert j. nmda-dependent superoxide production and neurotoxicity. nature. 1993 aug 5;364(6437):535-7.
Check Digit Verification of cas no
The CAS Registry Mumber 6384-92-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,8 and 4 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 6384-92:
(6*6)+(5*3)+(4*8)+(3*4)+(2*9)+(1*2)=115
115 % 10 = 5
So 6384-92-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1
6384-92-5Relevant articles and documents
Caged Bioactive Carboxylates. Synthesis, Photolysis Studies, and Biological Characterization of a New Caged N-Methyl-D-aspartic Acid
Gee, Kyle R.,Niu, Li,Schaper, Klaus,Hess, George P.
, p. 4260 - 4263 (1995)
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Pig growth urges the medicinal preparation preparation method of gene expression (by machine translation)
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, (2017/08/30)
The invention discloses a Pig growth gene expression urges the medicinal preparation preparation method, the present invention relates to a synthesis of amino acid derivatives, in particular to a Pig growth gene expression urges the medicinal preparation D - aspartic acid derivatives, N - methyl - D - aspartic acid of preparation method, through D - aspartic acid as the raw material, the D - aspartic acid with methanol and thionyl chloride reaction generating D - aspartic acid dimethyl ester hydrochloride, then with 40% formaldehyde of the woven fabric under the alkaline condition generating N - hydroxymethyl - D - aspartic acid, using pd/c as the catalyst under normal temperature and pressure hydrogenation to obtain N - methyl - D - aspartic acid; simple preparation method of the invention, the prepared product quality is stable, and in the preparation of environmental pollution, can promote the growth of livestock and at the same time, improve the utilization rate of the feed and the improvement of the quality of the carcass raising the Pig, popularization and application. (by machine translation)
Enantioselective synthesis of α-N-alkylamino acids via sultam-directed 'enolate' hydroxyamination
Oppolzer,Cintas-Moreno,Tamura,Cardinaux
, p. 187 - 196 (2007/10/02)
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