63923-56-8

Basic information

• Product Name: diethyl tritylphosphonate
• CAS NO: 63923-56-8
• Molecular Formula: C₂₃H₂₅O₃P
• Molecular Weight: 380.4166
• Mol File: 63923-56-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 505.8°C at 760 mmHg
• Flash Point: 272.8°C
• Density: 1.133g/cm³
• Vapor Pressure: 7.44E-10mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: diethyl tritylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl tritylphosphonate(63923-56-8)
• EPA Substance Registry System: diethyl tritylphosphonate(63923-56-8)

Safety Data

• Hazardous Substances Data: 63923-56-8(Hazardous Substances Data)

Usage

Description

Diethyl tritylphosphonate is a phosphonate ester with the molecular formula C24H27O3P. It is commonly used as a protecting group in organic synthesis to temporarily mask the reactivity of hydroxyl groups in a molecule.

Uses

Used in Pharmaceutical Synthesis:
Diethyl tritylphosphonate is used as a protecting group for hydroxyl groups in the synthesis of pharmaceuticals. It helps prevent unwanted side reactions during the synthesis process.
Used in Organic Synthesis:
Diethyl tritylphosphonate is used as a protecting group in the synthesis of complex organic molecules. Its stability and ease of use make it a valuable tool in organic chemistry for protecting hydroxyl groups and preventing side reactions.

Upstream product

• 596-43-0 bromo-triphenyl-methane 
• 122-52-1 triethyl phosphite 
• 852692-39-8 trityl-phosphonic acid ethyl ester chloride 
• 76-84-6 triphenylmethyl alcohol 
• 762-04-9 phosphonic acid diethyl ester 
• 3736-70-7 triphenylphosphonyl dichloride 
• 76-83-5 trityl chloride 
• 75-03-6 ethyl iodide 
• 60-29-7 diethyl ether 
• 71-43-2 benzene 
• 2303-76-6 sodium diethyl phosphite 
• 141-52-6 sodium ethanolate 
• 341-02-6 trityl tetrafluoroborate 

Relevant articles and documents

Reactions of 4-alkyl-1-trityl-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane cations with bases

The syntheses of 4-alkyl-1-trityl-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane tetrafluoroborates (alkyl group = Me, 4; Et, 5; t-Bu, 6) are described. Compounds 4, 5 and 6 in the presence of base (pyridine, DBU) or base (pyridine, DBU) plus H2O u

A facile synthesis and crystallographic analysis of seven trityl phosphorus compounds and two nickel(II) phosphine side-products

The syntheses and X-ray analyses of triphenylmethyl (trityl-Tr) phosphorus compounds are reported and the structural similarities, differences and 31P chemical shifts compared. A series of seven trityl-substituted phosphorus-containing compound

Aryl H-phosphonates. 7. Studies on the formation of phosphorus-carbon bond in the reaction of trityl and benzyl halides with dialkyl and diphenyl H-phosphonates

The reactions of H-phosphonate diesters with trityl and benzyl halides were investigated using 31P NMR spectroscopy. It was found that extensive oxidation, which usually accompanies the formation of trityl- or p-nitrobenzylphosphonates from the corresponding alkyl bromides in the Michaelis-Becker reaction, can be considerably suppressed or completely eliminated by reacting p-nitrobenzyl or trityl bromides with diphenyl H-phosphonate in acetonitrile in the presence of DBU.