63954-77-8

Basic information

• Product Name: 3 5-DIFLUOROSALICYLALDEHYDE 97
• Synonyms: 3 5-DIFLUOROSALICYLALDEHYDE 97;3,5-Difluoro-2-hydroxybenzaldehyde 98%;3,5-Difluorosalicaldehyde;3,5-Difluorosalicylaldehyde, 2,4-Difluoro-6-formylphenol;3,5-Difluorosalicylaldehyde 97%;3,5-Difluoro-2-hydroxybenzaldehyde98%;3,5-difluoro-2-hydroxybenzaldehde
• CAS NO: 63954-77-8
• Molecular Formula: C₇H₄F₂O₂
• Molecular Weight: 158.103
• EINECS: 1533716-785-6
• Product Categories: Aldehydes;C7;Carbonyl Compounds;Aryl Fluorinated Building Blocks;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 63954-77-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 87-91 °C(lit.)
• Boiling Point: 181.9 °C at 760 mmHg
• Flash Point: 63.8 °C
• Appearance: /
• Density: 1.464 g/cm³
• Vapor Pressure: 0.612mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 6.94±0.23(Predicted)
• CAS DataBase Reference: 3 5-DIFLUOROSALICYLALDEHYDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 3 5-DIFLUOROSALICYLALDEHYDE 97(63954-77-8)
• EPA Substance Registry System: 3 5-DIFLUOROSALICYLALDEHYDE 97(63954-77-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 63954-77-8(Hazardous Substances Data)

Usage

Uses

3,5-Difluorosalicylaldehyde may be used in the synthesis of Ni[CpFe(η5-C5H4)-C(O)CH=C(CH3)N-o-C6H4N=CH-(2-O,3,5-F2-C6H2)] (Cp = cyclopentyl) and Zn(salphenazine) complex.

General Description

3,5-Difluorosalicylaldehyde has been synthesized by employing 2,4-difluorophenol as a starting reagent.

InChI:InChI=1/C7H4F2O2/c8-5-1-4(3-10)7(11)6(9)2-5/h1-3,11H

Upstream product

• 367-27-1 2,4-difluorophenol 
• 68-12-2 N,N-dimethyl-formamide 
• 76-05-1 trifluoroacetic acid 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 939759-01-0 (R)-3-amino-6,8-difluorochroman 
• 760173-05-5 (R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione 
• 1034001-13-2 methyl 6,8-difluoro-2H-chromen-3-yl-carbamate 
• 1393847-43-2 C₂₄H₂₅F₂N₃O₃S 
• 98130-56-4 2-bromo-4,6-difluorophenol 
• 1216949-83-5 (S)-N-(3,5-difluorosalicylidene)-2-amino-1,1-di(3,5-di-tert-butylphenyl)-3-methyl-1-butanol 
• 1271772-91-8 3,5-difluoro-2-(prop-2-ynyloxy)benzaldehyde 
• 1269665-18-0 4,6-difluoro-2-((pyridin-4-ylmethylamino)methyl)phenol 
• 1269665-24-8 C₁₃H₁₀F₂N₂O 
• 1254062-13-9 2-(2,2-diethoxyethoxy)-3,5-difluorobenzaldehyde 
• 1204351-43-8 2-(2,4-difluoro-6-formylphenoxy)acetonitrile 
• 1159567-80-2 6-[4-(3,5-Difluoro-2-hydroxy-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one 
• 1132074-88-4 2-{[2-(4-{2-[3-((1R)-3-Diisopropylamino-1-phenyl-propyl)-4-hydroxy-phenyl]-ethoxy}-phenyl)-ethylamino]-methyl}-4,6-difluoro-phenol 

Relevant articles and documents

An improved method for the preparation of 3,5-difluorosalicylaldehyde and 3,5-difluorosalicylic acid

An improved method for the synthesis of 3,5-difluorosalicylic acid (3b) and 3,5-difluorosalicylaldehyde (3a) is described. 2,4-Difluorophenol (4) undergoes a formylation reaction to afford aldehyde 3a which is oxidized to the desired acid 3b. This method

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