939759-01-0

Upstream product

• 63954-77-8 3,5-difluorosalicylaldehyde 
• 1336950-06-1 6,8-difluorochroman-3-one 
• 1034001-13-2 methyl 6,8-difluoro-2H-chromen-3-yl-carbamate 
• 367-27-1 2,4-difluorophenol 
• 1034000-40-2 (R)-(6,8-difluorochroman-3-yl)carbamic acid ethyl ester 
• 1083157-18-9 C₁₂H₁₁F₂NO₄ 
• 1184842-84-9 C₁₂H₁₃F₂NO₅ 
• 1161948-00-0 C₁₂H₁₂ClF₂NO₄ 
• 1044596-89-5 (R)-2-amino-3-(2,4-difluorophenoxy)propionic acid 
• 1034000-36-6 (R)-methyl 6,8-difluorochroman-3-ylcarbamate 
• 1151797-94-2 6,8-difluoro-2H-chromene-3-carboxamide 
• 1043421-43-7 6,8-difluoro-2H-chromene-3-carbonitrile 

Downstream Products

• 760173-05-5 (R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione 
• 1393847-43-2 C₂₄H₂₅F₂N₃O₃S 

Relevant academic research and scientific papers

PROCESSES FOR PREPARING MEDICAMENTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND INTERMEDIATES FOR USE THEREIN

The present invention provides a compound of formula N wherein: X is CH2, oxygen or sulphur; R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino or dialkylamino group, wherein N is in the form of the individual R- and S-enantiomer or a mixture of the (R)- and (S)-enantiomer. The present invention also provides a compound of formula MA. The present invention also provides processes for preparing the above compounds, and processes involving their use. The compounds are particularly useful as intermediates in the synthesis of peripherally-selective inhibitors of dopamine-?-hydroxylase.

Process research for multikilogram production of etamicastat: A novel dopamine β-hydroxylase inhibitor

In order to develop a manufacturing route to etamicastat, three synthetic approaches to the pivotal chiral 3-aminochroman intermediate have been studied as well as four methods for the construction of the 2-aminoethyl imidazolethione fragment. The evoluti