63955-66-8Relevant articles and documents
Ligand-controlled selectivity in the Pd-catalyzed C-H/C-H cross-coupling of indoles with molecular oxygen
Beckers, Igor,Krasniqi, Besir,Kumar, Prashant,Escudero, Daniel,De Vos, Dirk
, p. 2435 - 2444 (2021/03/03)
Two indoles linked by a C-C bond have recently emerged as promising scaffolds in medicinal chemistry. Their synthesis, however, involves a multitude of reaction steps. So far, the direct C-H/C-H cross-coupling of two similar heteroaromatics lacking direct
Metal-Free Oxidative Cross Coupling of Indoles with Electron-Rich (Hetero)arenes
Caramenti, Paola,Nandi, Raj Kumar,Waser, Jerome
supporting information, p. 10049 - 10053 (2018/07/29)
A new method for the synthesis of bi-heteroaryls is reported, based on the umpolung of indoles with benziodoxol(on)e hypervalent iodine reagents (IndoleBX). The oxidative coupling of IndoleBX with an equimolar amount of electron-rich benzenes, indoles, pyrroles, and thiophenes proceeded under mild transition-metal-free conditions. Functionalized non-symmetrical bi-indolyl heterocycles were accessed efficiently. Introduction of a new type of C2-substituted indole benziodoxole reagents further allowed extending the scope of the reaction to NH unprotected and C3-alkylated indoles. The obtained bi-heterocycles are important building blocks in synthetic and medicinal chemistry, and could be easily transformed into more complex heterocyclic systems.
Palladium-Catalyzed Tandem Regioselective Oxidative Coupling from Indoles and Maleimides: One-Pot Synthesis of Indolopyrrolocarbazoles and Related Indolylmaleimides
An, Yu-Long,Yang, Zhen-Hua,Zhang, He-Hui,Zhao, Sheng-Yin
supporting information, p. 152 - 155 (2016/02/03)
An efficient Pd(II)-catalyzed approach for the direct synthesis of indolo[3,2-a]pyrrolo[3,4-c]carbazole-6,8-diones has been developed from both free and protected (NH) indoles and maleimides via a regioselective tandem oxidative coupling reaction. The yie
