6397-96-2

Upstream product

• 78-84-2 isobutyraldehyde 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Downstream Products

• 1361110-42-0 C₁₅H₂₁⁽²⁾H₂NO₂ 
• 91390-70-4 ((R)-1-Isopropyl-but-3-enyl)-((R)-1-phenyl-ethyl)-amine 
• 42454-75-1 (S)-3-Methyl-2-((R)-1-phenyl-ethylamino)-butyric acid 
• 133469-20-2 (R)-N-isobutyl-1-phenylethylamine 
• 1192740-50-3 (S)-3-Methyl-2-((R)-1-phenyl-ethylamino)-butyronitrile 
• 1361110-43-1 C₁₅H₂₁⁽²⁾H₂NO₂ 
• 42454-74-0 (R)-3-Methyl-2-((S)-1-phenyl-ethylamino)-butyric acid 
• 56949-82-7 (R,S)-3-methyl-2-(1-phenylethylamino)butyronitrile 
• 871735-68-1 4,4-difluoro-2-methyl-3-[(1R)-1-phenylethylamino]tridecan-5-one 

Relevant academic research and scientific papers

Asymmetric induction in the addition of enantiomerically pure H-phosphinate to chiral aldimines: diastereoselective generation of α-amino phosphinates with P,C-stereogenic centers

α-Amino phosphinates with P,C-stereogenic centers were prepared from a P-retained addition of (RP)-(?)-menthyl H-phenylphosphinate to (R)-aldimines with up to 86:14 dr under catalyst and solvent free condition at ambient temperature; the single

One-pot solvent-free reductive amination with a solid ammonium carbamate salt from CO2 and amine

Many amines are liquid and their handling is inconvenient compared with the corresponding solids. We transformed a liquid (S)-(-)-1-phenylethylamine 1 to the corresponding neutral solid form 2 by reacting with carbon dioxide. We performed reductive aminat

Synthesis of α, α-dideutero-β-amino esters

A straight forward entry to α, α-dideutero-β-amino esters starting from the corresponding imines and deuterated acetonitrile has been developed involving a two-step process.

Deracemization by enantioselective dehydrohalogenation. Synthesis of optically active compounds bearing a chiral axis.

This work describes the deracemization of 4-tert-butyl and 4-methylcyclohexylidene acetic acids bearing a chiral axis.Enantioselective dehydrohalogenation of prochiral species by chiral lithium amides allowed us to obtain e.e. as high as 82percent.A mecha

Asymmetric Syntheses of Amino Acids by Addition of Cyanide to the Schiff Bases in the Presence of Cyanide-Modified Hemin-Copolymer

Sterically controlled addition reactions of CN group to the Schiff bases by using CN-modified hemin-copolymer were carried out, and the optical yields (80-95 e.e.) of the resulting amino acids were much higher than that obtained without hemin-copolymer.

ASYMMETRIC ADDITION OF TRIS(TRIMETHYLSILYL) PHOSPHITE TO CHIRAL ALDIMINES

Addition of tris(trimethylsilyl) phosphite (2) to (+)-(R)-1-phenylethylaldimines (1) and methanolysis of addition products affords(+)-N-(1-phenyethyl)-1-aminoalkanophosphonic acids (3).Chemical yields and diastereomeric composition of 3 vary from 10 to 90