56949-82-7

Upstream product

• 151-50-8 potassium cyanide 
• 78-84-2 isobutyraldehyde 
• 618-36-0 rac-methylbenzylamine 
• 7677-24-9 trimethylsilyl cyanide 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 773837-37-9 sodium cyanide 
• 6397-96-2 (S)-N-isopropylmethylidene-1-phenylethylamine 

Downstream Products

• 640-68-6 D-Val-OH 
• 42454-74-0 (R)-3-Methyl-2-((S)-1-phenyl-ethylamino)-butyric acid 

Relevant academic research and scientific papers

Asymmetric strecker reaction with chiral amines: A catalyst-free protocol using acetone cyanohydrin in water

The synthesis of a series of new chiral α-aminonitriles was achieved in a diastereoselective Strecker reaction in a one-pot procedure with aldehydes, enantiopure amines, and acetone cyanohydrin in water. Primary and secondary amines derived from L-α-amino acids were used as sources of chirality. The reactions proceeded efficiently without any catalyst at room temperature. The diastereoselectivity of the process, and the configurational stability of new chiral α-aminonitriles were investigated. The identification of labile intermediates by NMR analysis, and a proposed mechanism and a model for the asymmetric induction are reported. The chemical transformation of proline-derived chiral α-amino-nitriles into chiral amino-diacids, aminols, and amides is reported. A series of new chiral α-aminonitriles was obtained in a diastereoselective Strecker reaction. Aldehydes were coupled with enantiopure amines derived from L-proline, L-phenylglycine, L-phenyl alanine, and L-tryptophan, in a one-pot procedure using acetone cyanohydrin in water. Copyright

Synthesis of α-aminonitriles catalyzed by montmorillonite K10 in the presence of dicationic phosphonium salt in water under ultrasonic effect

The synthesis of α-aminonitriles was successfully accomplished by the 1-pot 3-component reaction of several aldehydes with (S) - α- phenylethylamine and sodium cyanide in water in the presence of mont-morillonite K10 and dicationic phosphonium salt under

Iodine as a novel and efficient reagent for the synthesis of α-aminonitriles by a three-component condensation of carbonyl compounds, amines, and trimethylsilyl cyanide

A straightforward and general method has been developed for the synthesis of α-aminonitriles by simply combining aldehydes or ketones, amines, and trimethylsilyl cyanides in the presence of a catalytic amount of molecular iodine at room temperature.

Lithium perchlorate/diethylether catalyzed aminocyanation of aldehydes

A simple and efficient one-pot method was developed to give α- aminonitriles from aldehydes + amines + TMSCN in LPDE. Optically active α- aminonitriles were snythesized by using (S)-(-)- or (R) (+) α- methylbenzylamine, (S)-(-) α-methylbenzylamine affords

Thermodynamically Controlled 1,3-Asymmetric Induction in an Acyclic System: Equilibration of α-Amino Nitriles Derived from α-Alkylbenzylamines and Aldehydes

Acyclic α-amino nitriles 1, derived from α-alkylbenzylamines 3 and aldehydes 4 via a Strecker-type reaction, readily epimerize in MeOH at the newly emerged asymmetric center α to the cyano group.The equilibrium diastereomeric ratio :

Asymmetric Syntheses of Amino Acids by Addition of Cyanide to the Schiff Bases in the Presence of Cyanide-Modified Hemin-Copolymer

Sterically controlled addition reactions of CN group to the Schiff bases by using CN-modified hemin-copolymer were carried out, and the optical yields (80-95 e.e.) of the resulting amino acids were much higher than that obtained without hemin-copolymer.