64018-98-0

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 2-AMINO-5-METHOXYBENZOATE is used as a chemical intermediate for the synthesis of various drugs and pharmaceutical products. Its role in this industry is crucial for the development of new medications that address a range of health concerns.
Used in Medicinal Chemistry:
ETHYL 2-AMINO-5-METHOXYBENZOATE is used as a key component in the development of antihistamine and anti-inflammatory drugs. Its chemical properties make it a valuable asset in creating medications that can alleviate symptoms associated with allergies and inflammation.

InChI:InChI=1/C10H13NO3/c1-3-14-10(12)8-6-7(13-2)4-5-9(8)11/h4-6H,3,11H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 6705-03-9 2-Amino-5-methoxybenzoic acid 
• 10399-67-4 ethyl 2-nitro-5-(methoxy)benzoate 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 
• 610-37-7 5-hydroxy-2-nitrobenzoic acid 
• 452077-39-3 ethyl 5-hydroxy-2-nitrobenzoate 
• 63932-00-3 5-methoxy-2-nitrobenzoyl chloride 
• 1882-69-5 5-methoxy-2-nitro-benzoic acid 

Downstream Products

• 498557-42-9 2-[(4-ethoxy-1,4-dioxobutyl)amino]-5-methoxy-benzoic acid ethyl ester 
• 1103929-64-1 2-(2-(2-(ethoxycarbonyl)-4-methoxyphenylamino)-2-oxoethoxy)acetic acid 
• 1206805-66-4 ethyl 5-methoxy-2-(1H-pyrrol-1-yl)benzoate 
• 60374-42-7 6-Hydroxy-bentazon 

Relevant academic research and scientific papers

Overcoming the Deallylation Problem: Palladium(II)-Catalyzed Chemo-, Regio-, and Stereoselective Allylic Oxidation of Aryl Allyl Ether, Amine, and Amino Acids

We report herein a Pd(II)/bis-sulfoxide-catalyzed intramolecular allylic C-H acetoxylation of aryl allyl ether, amine, and amino acids with the retention of a labile allyl moiety. Mechanistically, the reaction proceeds through a distinct double-bond isomerization from the allylic to the vinylic position followed by intramolecular carboxypalladation and the β-hydride elimination pathway. For the first time, C-H oxidation of N-allyl-protected amino acids to furnish five-membered heterocycles through 1,3-syn-addition is established with excellent diastereoselectivity.

BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS

Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

RE[N(SiMe3)2]3-Catalyzed Guanylation/Cyclization of Amino Acid Esters and Carbodiimides

The example of rare-earth metal-catalyzed guanylation/cyclization of amino acid esters and carbodiimides is well-established, forming 4(3H)-2-alkylaminoquinazolinones in 65-96% yields. The rare-earth metal amides RE[N(TMS)2]3 (RE = Y, Yb, Nd, Sm, La; TMS = SiMe3) showed high activities, and La[N(TMS)2]3 performed best for a wide scope of the substrates.

Preparation technology of 6-hydroxy-bentazone

The invention discloses a preparation technology of 6-hydroxy-3-isopropyl-1H-benzo[c][1,2,6]thiadiazine-4(3H)-keto-2,2-dioxide. The preparation technology includes subjecting 5-chloro-2-nitrobenzoic acid serving as a raw material to hydrolysis reaction an

Synthesis of symmetric diester-functionalised Troeger's base analogues

The yields of ester-functionalised Troeger's base analogues are dramatically improved by incorporating an electron-donating group on the aromatic ring and/or enhancing solubil- ity of the aniline unit. In addition to 2,8-diester compounds, 1,7-, 3,9- and 4,10-diester-functionalised Troeger's base analogues have been prepared for the first time.

Synthesis of paullones with aminoalkyl side chains

Paullones 3 and 4 with aminoalkyl side chains in 2- or 3-position were synthesized as derivatives of kenpaullone 1. Both 3 and 4 showed the characteristic CDK1-inhibitory activity of the paullones and a modest antiproliferative activity on cultured human tumor cell lines. Hence, 3 and 4 appear to be suitable tools for affinity studies directed to find additional intracellular paullone targets.