64052-99-9

Upstream product

• 6921-64-8 4'-hydroxy-2'-methylacetophenone 
• 122-46-3 3-acetoxytoluene 
• 35633-35-3 2-methoxy-4-methylacetophenone 
• 221354-52-5 methyl 2-<4-methyl-2-methoxyphenyl>ethanethioate 
• 221354-43-4 2-<4-methyl-2-(methoxy)phenyl>-1-tetrahydro-2H-1,4-oxazin-4-yl-1-ethanthione 
• 238752-83-5 3-(3-butenyl)-6-methyl-2,3-dihydrobenzo[b]furan-2-one 
• 238752-84-6 3-(3-butenyl)-3,6-dimethyl-2,3-dihydrobenzo[b]furan-2-one 
• 238752-80-2 3-(3-butenyl)-3,6-dimethyl-2-methylene-2,3-dihydrobenzo[b]furan 
• 238752-82-4 methyl 2-[4-methyl-2-(methyloxy)phenyl]-5-hexenethioate 
• 331626-90-5 methyl 2-(2-methoxy-4-methylphenyl)propanethiolate 
• 65817-24-5 3,6-dimethyl-3H-benzo[b]furan-2-one 

Relevant academic research and scientific papers

The synthesis of a natural product family: From debromoisolaurinterol to the aplysins

Total syntheses of (±)-aplysin 1, (±)-debromoaplysin 2, (±)-isoaplysin 3, (±)-aplysinol 4, (±)-debromoaplysinol 5, (±)-aplysinal 6, (±)-isolaurinterol 7 and (±)-debromoisolaurinterol 8 are described. Key features are a diastereoselective, sulfur mediated radical cyclisation of diene 12 to give 35; a new radical to polar crossover sequence mediated by Bu3Sn that transforms diene 12 into (±)-debromoisolaurinterol 8; and a series of biomimetic cyclisation and oxidation reactions.