64068-24-2Relevant academic research and scientific papers
Synthesis of β-fluorophenethyl halopyridyl thiourea compounds as non-nucleoside inhibitors of HIV-1 reverse transcriptase
Venkatachalam,Uckun
, p. 2463 - 2472 (2007/10/03)
Synthesis of β-fluorophenethylamines was accomplished in three steps with an overall yield of 50%. Condensation of β-fluorophenethylamine hydrochloride with thiocarbonylimidazole derivative derived from halopyridyl amines in dimethylformamide furnished the desired thiourea compounds as crystalline solids. Several of the β-fluorophenethyl thiourea compounds inhibited HIV-1 reverse transcriptase (RT) at nanomolar to low micromolar concentrations.
FLUORO-2 PHENYL-2 AMINO-1 ETHANE: OBTENTION DES ENANTIOMERES, CONFIGURATION ABSOLUE ET EMPLOI COMME AGENT CHIRAL DE DERIVATION
Hamman, S.
, p. 377 - 388 (2007/10/02)
2-Fluoro-2-phenyl-1-aminoethane was synthesized from styrene.The enantiomers were separated and their absolute configurations were determined: the specific rotation of the amine with an R configuration is D20=-37.7 deg in methanol.This amine
A NOVEL SYNTHESIS OF α-FLUOROOACETONITRILES. APPLICATION TO A CONVENIENT PREPARATION OF 2-FLUORO-2-PHENETYLAMINES
LeTourneau, Michael E.,McCarthy, James R.
, p. 5227 - 5230 (2007/10/02)
α-Fluorophenylacetonitriles (3) are readily prepared by the treatment of the corresponding benzaldehyde cyanohydrin trimethylsilylethers (2) with diethylaminosulfur trifluoride (DAST).This method for the introduction of fluorine alpha to the cyano group is also applicable to the cyanohydrin trimethylsilylethers of aromatic ketones.Diborane reduction of the α-fluorophenylacetonitriles (3) yields 2-fluoro-2-phenethylamines (4).
