64168-08-7

Usage

Uses

Used in Organic Synthesis:
1-Benzyl-4-dimethylaminopiperidine is used as a reagent in organic synthesis for its ability to act as a catalyst or a building block in the synthesis of various molecules. Its unique structure allows it to facilitate multiple types of chemical reactions, contributing to the creation of a wide range of organic compounds.
Used in Pharmaceutical Chemistry:
In the pharmaceutical industry, 1-Benzyl-4-dimethylaminopiperidine is utilized as a reagent for the synthesis of pharmaceuticals. Its structural features make it a valuable component in the development of new drugs, potentially enhancing the efficacy and selectivity of medicinal compounds.
Used as a Local Anesthetic:
1-Benzyl-4-dimethylaminopiperidine is used as a local anesthetic due to its ability to inhibit voltage-gated sodium channels, thereby reducing nerve impulse transmission and providing pain relief without affecting consciousness.
Used as a Research Compound:
In scientific research, 1-Benzyl-4-dimethylaminopiperidine serves as a compound of interest for studying its pharmacological properties and potential applications in medicine. Its exploration can lead to a better understanding of its mechanisms of action and possible therapeutic uses.

Upstream product

• 100-46-9 benzylamine 
• 24686-78-0 1-Benzoyl-4-piperidone 
• 27691-43-6 1-(benzylsulphanyl)-4-Nitrobenzene 
• 50533-97-6 dimethyl-piperidin-4-yl-amine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 506-59-2 N,N-dimethylammonium chloride 
• 84157-05-1 phenyl(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 98-88-4 benzoyl chloride 
• 93865-36-2 (4-dimethylaminopiperidin-1-yl)phenylmethanone 
• 50-00-0 formaldehyd 
• 50541-93-0 4-amino-1-benzylpiperidine 

Downstream Products

• 50533-97-6 dimethyl-piperidin-4-yl-amine 

Relevant academic research and scientific papers

Discriminating non-ylidic carbon-sulfur bond cleavages of sulfonium ylides for alkylation and arylation reactions

A sulfonium ylide participated alkylation and arylation under transition-metal free conditions is described. The disparate reaction pattern allowed the separate activation of non-ylidic S-alkyl and S-aryl bond. Under acidic conditions, sulfonium ylides serve as alkyl cation precursors which facilitate the alkylations. While under alkaline conditions, cleavage of non-ylidic S-aryl bond produces O-arylated compounds efficiently. The robustness of the protocols were established by the excellent compatibility of wide variety of substrates including carbohydrates.

Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase

The recognition that aberrant angiogenesis contributes to the pathology of inflammatory diseases, cancer, and myocardial ischemia has generated considerable interest in the molecular mechanisms that regulate blood vessel growth. The receptor tyrosine kinase Tie-2 is expressed primarily by vascular endothelial cells and is critical for embryonic vasculogenesis. Interference with the Tie-2 pathway by diverse blocking agents such as soluble Tie-2 receptors, anti-Tie-2 intrabodies, anti-Ang-2 antibodies, and peptide-F c conjugates has been shown to suppress tumor growth in xenograft studies. An alternative strategy for interfering with the Tie-2 signaling pathway involves direct inhibition of the kinase functions of the Tie-2 receptor. Herein we describe the development of alkynylpyrimidine amide derivatives as potent, selective, and orally available ATP-competitive inhibitors of Tie-2 autophosphorylation.

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

A 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented by the generalformula (1): [Chemical formula 1] (1) or a pharmaceutically acceptable saltthereof. They are useful as a therapeutic/preventive agent for diabetes, diabeticnephropathy, or glomerulosclerosis.

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE

Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.

Antinociceptive effects of 1-acyl-4-dialkylaminopiperidine and 1-alkyl-4-dialkylaminopiperidine in mice: Structure-activity relation study of matrine-type alkaloids

We previously reported that (+)-matrine and (+)-allomatrine have antinociceptive properties mediated mainly through the activation of κ-opioid receptors. 1-Acyl-4-dialkylaminopiperidines were synthesized as the simplest derivatives of matrine, and the structure-activity relations were examined by the acetic acid-induced abdominal contraction test. The antinociceptive potencies of 1-alkyl-4-dialkylaminopiperidines were significantly lower than those of the corresponding 1-acyl-4- dialkylaminopiperidines. These findings suggest that the amide group of (+)-matrine is an essential functional group that influences antinociceptive potency.

Pharmaceutical compositions and methods of inhibiting gastric acid secretion

Pharmaceutical compositions and methods of inhibiting gastric acid secretion by administering 1-(9-xanthenyl) amino-substituted-piperidines and pyrrolidines and new 1-(9-xanthenyl) amino-piperidine compounds.