64193-03-9

Upstream product

• 18328-11-5 3-benzyl propionaldehyde 
• 1826-67-1 vinyl magnesium bromide 
• 637-59-2 1-Bromo-3-phenylpropane 
• 107-02-8 acrolein 
• 591-50-4 iodobenzene 
• 3360-41-6 4-phenyl-butan-1-ol 

Downstream Products

• 39669-95-9 (E)-hexa-3,5-dien-1-ylbenzene 
• 64193-04-0 acetic acid 1-(3-phenylpropyl)allyl ester 
• 864272-98-0 2-[1-(3-phenyl-propyl)-allyl]-isoindole-1,3-dione 

Relevant academic research and scientific papers

Diastereoselective C?H Bond Amination for Disubstituted Pyrrolidines

We report herein the improved diastereoselective synthesis of 2,5-disubstituted pyrrolidines from aliphatic azides. Experimental and theoretical studies of the C?H amination reaction mediated by the iron dipyrrinato complex (AdL)FeCl(OEt2) provided a model for diastereoinduction and allowed for systematic variation of the catalyst to enhance selectivity. Among the iron alkoxide and aryloxide catalysts evaluated, the iron phenoxide complex exhibited superior performance towards the generation of syn 2,5-disubstituted pyrrolidines with high diastereoselectivity.

Switchable Site-Selective Catalytic Carboxylation of Allylic Alcohols with CO2

A switchable site-selective catalytic carboxylation of allylic alcohols has been developed in which CO2 is used with dual roles, both facilitating C?OH cleavage and as a C1 source. This protocol is characterized by its mild reaction conditions, absence of stoichiometric amounts of organometallic reagents, broad scope, and exquisite regiodivergency which can be modulated by the type of ligand employed.

Alkene migration to the end-terminal carbon bearing a phenyl group over a chiral siloxy carbon center in Heck reaction

Abstract The Heck reaction of aryl bromide with a terminal alkene substrate having a chiral center at the allylic position and a phenyl substituent at another terminal carbon is reported. An alkene migration to the phenyl-substituted end carbon is observed, along with the typical Heck reaction. This zipper-type migration occurs through multiple internal carbon bonds, and the stereochemistry of the internal chiral center is completely retained during this process.

A convenient and versatile method for the preparation of α-hydroxymethyl ketone derivatives from the corresponding allyl silyl ethers or allyl carboxylates

The ozonolysis of 1-substituted allyl silyl ethers or 1-substituted allyl carboxylates followed by treatment with bases gave the corresponding α-silyloxymethyl- or α-acyloxymethyl-ketones in good yields. It is proposed to proceed via the corresponding α-silyloxy- or α-acyloxyaldehydes intermediates followed by 1,4-group migration. The results of theoretical calculations are applicable to explain the experimental results.

Unified, radical-based approach for the synthesis of spiroketals

Functionalization of S-(3-chloro-2-oxo-propyl)-O-ethyl xanthate 1 by two consecutive xanthate transfer reactions, followed by spirocyclization of the resulting dihydroxy ketones, provides a flexible and highly convergent access to diversely substituted spiroketals, containing five-, six-, and seven-membered rings.

AMINE-BASED AND AMIDE-BASED INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) ENZYME ACTIVITY AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT OF DISEASES

Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.