642-04-6

Usage

Uses

2,3,5,6-Tetraphenylpyrazine exhibits antidiabetic activity in sucrose-loaded and streptozotocin-induced diabetic rat models.

InChI:InChI=1/C28H20N2/c1-5-13-21(14-6-1)25-26(22-15-7-2-8-16-22)30-28(24-19-11-4-12-20-24)27(29-25)23-17-9-3-10-18-23/h1-20H

Upstream product

• 668-94-0 4,5-diphenyl-1H-imidazole 
• 100-39-0 benzyl bromide 
• 574-13-0 benzoin E-oxime 
• 574-15-2 (E)-benzil monooxime 
• 522-34-9 Diphenylglyoxime 
• 572-45-2 benzil dioxime 
• 3723-23-7 2-amino-1,2-diphenylethanone 
• 631-61-8 ammonium acetate 
• 93-59-4 Perbenzoic acid 
• 67-66-3 chloroform 
• 3263-79-4 2,3,4,5-tetraphenyl-1H-pyrrole 
• 572-18-9 (1E,2E)-1,2-diphenylethane-1,2-dione bis(phenylhydrazone) 
• 81640-85-9 N-benzoyl-N-(α-benzoylbenzyl)aniline 
• 81640-86-0 N-(α-benzoylbenzyl)-N-formylaniline 

Downstream Products

• 32347-89-0 2,3,5,6-tetraphenyl-piperazine 
• 3263-79-4 2,3,4,5-tetraphenyl-1H-pyrrole 

Relevant academic research and scientific papers

Antihyperglycemic activity of 2-methyl-3,4,5-triaryl-1H-pyrroles in SLM and STZ models

Various 3,4,5-triarylpyrroles were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded (SLM) and/or streptozotocin-induced (STZ) diabetic rat models. Three of the test compounds, 2-methyl-4,5-diphenyl-3-substituted-phe

Rotation Restricted Emission and Antenna Effect in Single Metal-Organic Frameworks

Aggregation induced-emission (AIE) and antenna effects are important luminescence behaviors. Thus, investigating their emission mechanisms and revealing their behaviors have become critical but challenging. Here we design and prepare metal-organic framewo

Experimental and computational study of metal-free Br?nsted acidic ionic liquid catalyzed benzylic C(sp3)–H bond activation and C–N, C–C cross couplings

Metal and solvent free synthesis of tetrasubstituted imidazoles and tetrasubstituted pyrazines from 1,2-diketones and aliphatic amines is studied experimentally and computationally. Various ionic liquids (ILs) are taken as a catalyst in 10 mol% for the re

One-pot synthesis of 2,3,5-substituted 1H-pyrroles via the reaction of terminal acetylenes with nitriles and EtAlCl2 catalyzed by Сp2TiCl2

A new one pot method for the synthesis of 2,3,5-substituted 1H-pyrroles in moderate to good yields (58–77%) based on multicomponent reaction of terminal acetylenes with nitriles and EtAlCl2 in the presence of Сp2TiCl2 cata

Four-phenyl pyrazine small molecule derivatives, four-phenyl pyrazine polymer and aggregation induced material

The invention discloses a tetrapherylpyrazine low-molecular-weight derivate, a tetrapherylpyrazine polymer and an aggregation-induced emission material. The tetrapherylpyrazine low-molecular-weight derivate is of a structure as shown in a formula (1), whe

Phosphine Supported Ruthenium Nanoparticle Catalyzed Synthesis of Substituted Pyrazines and Imidazoles from α-Diketones

A new methodology has been developed for the synthesis of highly substituted nitrogen heterocycles such as pyrazines and imidazoles starting from α-diketones using phosphine supported ruthenium nanoparticles (RuNPs) as catalysts. Ruthenium nanoparticles Ru1-Ru4 supported with different phosphines such as dbdocphos, dppp, DPEphos, and Xantphos are screened, of which Ru1 and Ru4 are found to be the most active. Interestingly, aryl-substituted and alkyl-substituted α-diketones produced different products: namely, pyrazine and imidazoles, respectively. This reaction methodology has been applied to the synthesis of a key intermediate (2m) of the marine cytotoxic natural product Dragmacidin B and an estrogen receptor (2l). This work represents the first examples of pyrazines prepared by RuNPs.

Combining photo-cleavable and hydrogen-abstracting groups in quinoxaline with thioether bond as hybrid photoinitiator

We synthesized four diphenylquinoxaline derivatives (SQs) with phenyl-thioether units, which combine photo-cleavable and hydrogen-abstracting groups in one molecule. The photochemistry and photopolymerization of SQs were investigated. SQs possess suitable

An Improved Synthesis of Multi-Substituted Pyrazines under Catalyst- and Solvent-Free Conditions

A one-pot pseudo four-component reaction between a variety of 2-hydroxy-1,2-diarylethanone derivatives and ammonium acetate or amines has been developed to synthesize substituted pyrazines under catalyst-free and solvent-free conditions. This procedure provides a synthetic method to access pyrazine derivatives in excellent yields under green conditions.

SnCl2·2H2O-Catalyzed Solvent-Free Synthesis of α-Amino Ketones and Tetrasubstituted Pyrazines

Solvent-free reaction of various anilines with α-hydroxy ketones catalyzed by SnCl2·2H2O provides α-amino ketones in excellent yields. While a similar reaction with aliphatic amines is applicable for the synthesis of substituted pyrazines, SnCl2·2H2O permits versatility in the solvent-free reaction of α-hydroxy ketones with ammonium acetate to give the corresponding substituted pyrazines in good to excellent yields.

Cocamidopropyl betaine catalyzed benzoin condensation and pseudo-four-component reaction of the in situ formed benzoin in water

An improved synthesis of benzoins, as key synthetic building blocks, and substituted pyrroles in micelle medium using a very small amount of cocamidopropyl betaine in water is described. In this one-pot strategy, benzoin condensation of aldehydes and further pseudo-four-component reaction of the in situ formed benzoin with 1,3-dicarbonyls, and ammonium acetate gave excellent yields of the desired pyrrole products.