64264-15-9

Usage

Uses

Used in Pharmaceutical Industry:
ABBYPHARMA AP-10-1464 is used as a chemical intermediate for the synthesis of various pharmaceutical ingredients and active pharmaceutical ingredients (APIs). Its versatility allows it to be a building block in the production of a wide range of drugs, including anti-cancer agents, antibiotics, and other therapeutic compounds.
Used in Drug Development:
ABBYPHARMA AP-10-1464 is used as a key component in the development of new pharmaceuticals. Its chemical structure and properties make it an essential part of creating innovative and effective treatments for various medical conditions.
Used in Quality Assurance:
ABBYPHARMA AP-10-1464 is used to ensure the high purity and quality of pharmaceutical products. Its presence in the synthesis process helps maintain the standards required for use in the pharmaceutical industry, contributing to the safety and efficacy of medications.

Upstream product

• 694-59-7 pyridine N-oxide 
• 51953-18-5 pyrimidine-4(3H)-one 
• 51285-26-8 pyridine-2-carboxamidine hydrochloride 

Downstream Products

• 97603-38-8 4-chloro-2-pyridin-2-yl-pyrimidine 
• 97603-53-7 (2-Pyridin-2-yl-pyrimidin-4-yl)-hydrazine 

Relevant academic research and scientific papers

Structure-activity relationship of thiopyrimidines as mGluR5 antagonists

Structure-activity relationship investigations of the thiopyrimidine (1), an HTS hit with micromolar activity as a metabotropic glutamate receptor 5 (mGluR5) antagonist, led to compounds with sub-micromolar activity.

NEW COMPOUNDS

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

Reactions of pyridine N-oxide with some hydroxypirimidines in the presence of platinated palladium-carbon catalyst

The reactions of pyridine N-oxide (1) with hydroxypirimidine derivatives (2-7) in the presence of platinated palladium-carbon (Pd-Pt/C) catalyst were studied. 5-Hydroxypyrimidine (2), 4-hydroxypyrimidines (3 and 4) and 1-methyl-2-pyrimidinone (6) gave the corresponding dimers and 2-pyridyl derivatives by this condensation with high regioselectivity at the dehydrogenative position, while 2-hydroxypyrimidine (5) gave only the 2-pyridyl derivative. 2,4-Dihydroxypirimidine (7) did not react under similar reaction conditions.All the products obtained in these reactions are new compounds.These dimerization reactions may be useful for the synthesis of the dimers of N-heteroaromatic compounds.Keywores - pyridine N-oxide; hydroxypyrimidine; platinated palladium-carbon catalyst; bipyrimidine; dimer; dehydrogenative dimerization; regioselectivity.