97603-38-8

Basic information

• Product Name: 4-chloro-2-pyridin-2-ylpyrimidine
• Synonyms: 4-chloro-2-pyridin-2-ylpyrimidine
• CAS NO: 97603-38-8
• Molecular Formula: C₉H₆ClN₃
• Molecular Weight: 191.61704
• Mol File: 97603-38-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-chloro-2-pyridin-2-ylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-pyridin-2-ylpyrimidine(97603-38-8)
• EPA Substance Registry System: 4-chloro-2-pyridin-2-ylpyrimidine(97603-38-8)

Safety Data

• Hazardous Substances Data: 97603-38-8(Hazardous Substances Data)

Usage

General Description

4-chloro-2-pyridin-2-ylpyrimidine is a chemical compound with the molecular formula C9H6ClN3. It is a pyridine-based heterocyclic compound that contains a chloro substituent at the 4-position and a pyrimidine ring fused to the pyridine ring at the 2-position. 4-chloro-2-pyridin-2-ylpyrimidine has been used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological and pharmacological activities, including as an antitumor agent and an inhibitor of protein kinases. Additionally, 4-chloro-2-pyridin-2-ylpyrimidine has been reported to exhibit herbicidal properties, making it a potentially useful compound in the development of herbicides.

Upstream product

• 64264-15-9 2-pyridin-2-yl-3H-pyrimidin-4-one 
• 51285-26-8 pyridine-2-carboxamidine hydrochloride 

Downstream Products

• 97603-53-7 (2-Pyridin-2-yl-pyrimidin-4-yl)-hydrazine 

Relevant articles and documents

Structure-activity relationship of thiopyrimidines as mGluR5 antagonists

Structure-activity relationship investigations of the thiopyrimidine (1), an HTS hit with micromolar activity as a metabotropic glutamate receptor 5 (mGluR5) antagonist, led to compounds with sub-micromolar activity.

Preparation of Triazolopyrimidines as Potential Antiasthma Agents

With the use of the human basophil histamine release assay, 5-aryl-2-aminotriazolopyrimidines were found to be active as mediator release inhibitors.These compounds were prepared by reacting arylamidines with sodium ethyl formylacetate or with ethyl propiolate to give pyrimidinones.Treatment with phosphorus oxychloride gave a chloropyrimidine, which was converted to a hydrazinopyrimidine with hydrazine.Cyclization, using cyanogen bromide, gave the triazolopyrimidines, after a Dimroth rearrangement.Following a structure-activity evaluation, the5--2-amino (8-10), 5-(3-bromophenyl)-2-amino (8-13), 5--2-amino (8-11), and 5-(4-pyridinyl)-2-amino (6-7) compounds were found to have the best activity.They were chosen for further pharmacological and toxicological study.