64291-41-4

Basic information

• Product Name: ACETAGASTRODINE
• Synonyms: ACETAGASTRODINE;[(2R,3R,4S,5R,6S)-3,4,5-triacetyloxy-6-[4-(hydroxymethyl)phenoxy]oxan- 2-yl]methyl acetate;Acegastrodine;4-(Hydroxymethyl)phenyl β-D-glucopyranoside 2,3,4,6-tetraacetate;2,3,4,6-Tetra-O-acetyl-4-(hydroxymethyl)phenyl-b-D-glucopyranoside;(2R,3R,4S,5R,6S)-2-(AcetoxyMethyl)-6-(4-(hydroxyMethyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate;b-D-Glucopyranoside,4-(hydroxymethyl)phenyl, 2,3,4,6-tetraacetate
• CAS NO: 64291-41-4
• Molecular Formula: C₂₁H₂₆O₁₁
• Molecular Weight: 454.147512
• EINECS: 200-258-5
• Mol File: 64291-41-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 170-171 °C(Solv: ethanol (64-17-5))
• Boiling Point: 551.4 °C at 760 mmHg
• Flash Point: 184 °C
• Appearance: /
• Density: 1.33 g/cm³
• Storage Temp.: 2-8°C
• PKA: 14.42±0.10(Predicted)
• CAS DataBase Reference: ACETAGASTRODINE(CAS DataBase Reference)
• NIST Chemistry Reference: ACETAGASTRODINE(64291-41-4)
• EPA Substance Registry System: ACETAGASTRODINE(64291-41-4)

Safety Data

• Hazardous Substances Data: 64291-41-4(Hazardous Substances Data)

Usage

General Description

Acetagastrodine is a chemical compound with the formula C26H27N3O2. It is a potent and selective antagonist of the histamine H2 receptor, which is found in the stomach and helps to regulate the production of gastric acid. Acetagastrodine is used as a medication to treat conditions such as gastric ulcers, duodenal ulcers, gastroesophageal reflux disease (GERD), and other conditions that involve excessive production of gastric acid. By blocking the H2 receptor, acetagastrodine reduces the amount of acid produced in the stomach, providing relief from the symptoms of these conditions. It is typically administered orally and is well-absorbed from the gastrointestinal tract, with a relatively long duration of action. Overall, acetagastrodine is an effective and widely used medication for the treatment of acid-related stomach disorders. So, it is used for antiulcer treatment.

Upstream product

• 623-05-2 (4-hydroxyphenyl)methanol 
• 572-09-8 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 492-61-5 β-D-glucose 
• 3947-62-4 2,3,4,6-tetra-O-acetyl-β-D-glucopyranose 
• 62499-27-8 gastrodin 
• 64-19-7 acetic acid 
• 6919-96-6 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 
• 106-44-5 p-cresol 
• 2887-07-2 4-formylphenyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 
• 78617-45-5 4-(bromomethyl)phenyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 
• 14581-78-3 4-methylphenyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 
• 604-69-3 β-D-glucose pentaacetate 

Downstream Products

• 59252-47-0 4-(tetra-O-acetyl-β-D-glucopyranosyloxy)benzyl acetate 
• 78617-45-5 4-(bromomethyl)phenyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 
• 129395-85-3 1-O-(Perfluoro-2-propoxypropionyl-O-benzyl)-2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 
• 62499-27-8 gastrodin 

Relevant articles and documents

Neuroprotective activity of different monosaccharide-modified gastrodin analogs

Gastrodin is a very important and well-known bioactive glycoside compound in Chinese medicine. It is also known as a drug with neuroprotective function. Here, a practical diversified synthesis of a series of gastrodin analogs was reported, which involved four-step procedures consisting of bromination, oxidation, etherification, and reduction. Various gastrodin analogs were obtained in good yields. The compound 4c in this study has a good neuroprotective function: it can significantly downregulate tumor necrosis factor-α and inducible nitric oxide synthase protein levels. The results of this study can provide a research basis for the development of neuroprotective drugs.

Gastrodine drug and its composition and use thereof

The invention relates to a gastrodin medicine, and a composition and a use thereof, and also relates to a gastrodin derivative, and a preparation method and a use thereof. The gastrodin derivative has good storage stability, and is suitable for preparing medicines for increasing the cerebral blood flow, alleviating the cerebral vasospasm, calming, sleeping, easing pains, and treating or preventing Alzheimer's syndrome.