64325-12-8Relevant academic research and scientific papers
Heterocyclic Spirocyclohexadienones from Substituted Phenols
Moehrle, H.,Schake, D.
, p. 1859 - 1868 (2007/10/03)
Mannich bases were prepared from substituted phenols with aliphatic amines and formaldehyde.Amine exchange with N-methyl-2-naphthylamine followed by a Hofmann Martius rearrangement gave rise to o,o'-amino-hydroxy-diphenylmethane derivatives.Under cyclization conditions some of these compounds produced spirocyclohexadienones, which are the ipso analogs to the hypothetic intermediates postulated in the aminomethylation mechanism of phenols. - Keywords: Mannich Reaction; Phenol Dienone Tautomerism; Hofmann Martius Rearrangement
SELECTIVE FUNCTIONALIZATION OF AROMATIC COMPOUNDS. I. ORTHO-AMINOALKYLATION OF PHENOL AND o-tert-BUTYLPHENOL
Salakhutdinov, N. F.,Krysin, A. P.,Koptyug, V. A.
, p. 664 - 665 (2007/10/02)
The aminomethylation of phenol in a complex with β-cyclodextrin, formalin, and dialkylamine gives the mono-ortho-aminoalkyl derivative.In contrast to this, for o-tert-butylphenol selective ortho-aminoalkylation can be realized without complex formation under the normal conditions of the Mannich reaction.
