64346-70-9

Basic information

• Product Name: N,N-diethyl-2-methoxyaniline
• Synonyms: benzenamine, N,N-diethyl-2-methoxy-; N,N-Diethyl-2-methoxyaniline
• CAS NO: 64346-70-9
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.2588
• Mol File: 64346-70-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 230°C at 760 mmHg
• Flash Point: 66.6°C
• Density: 0.971g/cm³
• Vapor Pressure: 0.0673mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: N,N-diethyl-2-methoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-2-methoxyaniline(64346-70-9)
• EPA Substance Registry System: N,N-diethyl-2-methoxyaniline(64346-70-9)

Safety Data

• Hazardous Substances Data: 64346-70-9(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 90-04-0 2-methoxy-phenylamine 
• 75-03-6 ethyl iodide 
• 321-28-8 1-fluoro-2-methoxybenzene 
• 109-89-7 diethylamine 
• 529-28-2 4-iodoanisol 
• 64-17-5 ethanol 
• 91-23-6 2-Nitroanisole 
• 91-16-7 1,2-dimethoxybenzene 

Downstream Products

• 2628-70-8 N¹,N¹-diethyl-2-methoxy-p-phenylenediamine 

Relevant articles and documents

One-pot photo-reductive N-alkylation of aniline and nitroarene derivatives with primary alcohols over Au-TiO2

We report the photo-catalytic N-alkylation of aniline by Au-TiO 2. We successfully alkylate aniline with several primary alcohols. The combined selectivities of mono- and di-alkylated products were always in excess of 70% and dependent on the alkylating alcohol used. A one-pot reaction from nitrobenzene was found to be possible with several substrates. Preliminary experiments showed that this approach could be adopted for the production of lactams using terminal amino-alcohols. The Royal Society of Chemistry 2013.

Direct Substitution of Aromatic Ethers by Lithium Amides. A New Aromatic Amination Reaction

Reaction of lithiated dialkylamines with methoxy aromatics in refluxing THF leads to products resulting from a direct ipso-substitution.Especially with lithiated secondary amines high conversions and selectivities are achieved.Sulfonyl-substituted aromatics react equally well, but halogenated aromatics give rise to side-products arising from a competing pathway via aryne intermediates.The scope and mechanistic implications of this novel nucleophilic amination reaction are described.