64357-92-2

Usage

InChI:InChI=1/C16H16O2/c1-3-12-4-6-13(7-5-12)16(17)14-8-10-15(18-2)11-9-14/h4-11H,3H2,1-2H3

Upstream product

• 696-62-8 para-iodoanisole 
• 63139-21-9 4-ethylphenylboronic acid 
• 199620-14-9 chromium⁽⁰⁾ hexacarbonyl 
• 67-66-3 chloroform 
• 16331-45-6 p-ethylbenzoyl chloride 
• 100-66-3 methoxybenzene 
• 100-41-4 ethylbenzene 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 1036954-94-5 1-ethyl-4-(4-methoxybenzyl)benzene 

Relevant academic research and scientific papers

Binuclear Palladium Complex Immobilized on Mesoporous SBA-16: Efficient Heterogeneous Catalyst for the Carbonylative Suzuki Coupling Reaction of Aryl Iodides and Arylboronic Acids Using Cr(CO)6 as Carbonyl Source

Abstract: In this study, a binuclear palladium complex immobilized on the organo-functionalized SBA-16 was prepared and structurally characterized by routine techniques. Characterizations indicated that the mesostructure of SBA-16 was maintained after the immobilization of palladium complex. Then, the prepared nanomaterial was applied as a heterogeneous catalyst in the carbonylative Suzuki coupling reaction of aryl iodides with arylboronic acids using Cr(CO)6 as carbonyl source. The catalyst was efficiently promoted the coupling reactions of various aryl iodides and arylboronic acids to give the corresponding diaryl ketones in excellent yields. Moreover, the catalyst was readily recovered by filtration and could be reused for seven cycles without losing its structural integrity and catalytic activity. Graphic Abstract: [Figure not available: see fulltext.].

Method for selectively synthesizing benzyl trifluoromethyl sulfide

The invention discloses a method for selectively synthesizing benzyl trifluoromethyl sulfide. The method comprises the following steps: taking alkyl aromatic hydrocarbon ArCHR1R2 as a raw material; and under irradiation by a blue light lamp, in a solution, under the argon atmosphere and under presence of a small amount of potassium carbonate, taking 4CzIPN as a photocatalyst to react with 2-((trifluoromethyl) sulfenyl)isoindoline-1, 2, 3, 4-thiadiazole to obtain photocatalyst 4CzIPN shown in the benzyl trifluoromethyl sulfide ArCR1R2SCF3 (3), wherein the photocatalyst 4CzIPN has the followingstructure shown in the specification. According to the method, the reaction conditions are mild, no oxidizing agent or high-temperature condition is needed, residues of transition metal are avoided, and benzyl trifluoromethyl sulfide is directly obtained from alkyl arene and trifluoromethyl sulfide reagents which are stable and easy to obtain.

Palladium Catalyzed Carbonylative Coupling for Synthesis of Arylketones and Arylesters Using Chloroform as the Carbon Monoxide Source

We describe a modular, palladium catalyzed synthesis of aryl(hetero)aryl benzophenones and aryl benzoates from aryl(hetero)aryl halides using CHCl3 as the carbonyl source in the presence of KOH. The reaction occurs in tandem through an initial carbonylation to generate an aroyl halide, which undergoes coupling with arylboronic acids, bornonates, and phenols. Direct carbonylative coupling of indoles at the third position has also been accomplished under slightly modified reaction conditions by in situ activation of the C-H bond. Notably, CHCl3 is a convenient and safe alternation of CO gas, provides milder reaction conditions with high functional group tolerance, and gives the products in moderate to good yields.

SPIROHETEROCYCLIC GLYCOSIDES AND METHODS OF USE

Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.