6436-60-8

Basic information

• Product Name: Methyl 2-Methylthiazole-4-carboxylate
• Synonyms: methyl 2-methyl-1,3-thiazole-4-carboxylate
• CAS NO: 6436-60-8
• Molecular Formula: C₆H₇NO₂S
• Molecular Weight: 157.19028
• Mol File: 6436-60-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 224.7°C at 760 mmHg
• Flash Point: 89.7°C
• Appearance: /
• Density: 1.244g/cm³
• Vapor Pressure: 0.0898mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 2-Methylthiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-Methylthiazole-4-carboxylate(6436-60-8)
• EPA Substance Registry System: Methyl 2-Methylthiazole-4-carboxylate(6436-60-8)

Safety Data

• Hazardous Substances Data: 6436-60-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H7NO2S/c1-4-7-5(3-10-4)6(8)9-2/h3H,1-2H3

Upstream product

• 6436-58-4 methyl 2-methyl-4,5-dihydrothiazole-4-carboxylate 
• 336193-86-3 methyl (4R)-2-methylthiazolidine-4-carboxylate 
• 18598-63-5 L-cysteine methyl ester hydrochloride 
• 75-07-0 acetaldehyde 
• 35272-15-2 2-methylthiazole-4-carboxylic acid 
• 74-88-4 methyl iodide 
• 7425-63-0 methyl 3-bromo-2-oxopropanoate 
• 62-55-5 thioacetamide 
• 1393377-75-7 dimethyl (2R,2'R)-3,3'-disulfanediylbis(2-azidopropanoate) 
• 108-24-7 acetic anhydride 
• 2519-89-3 (4R)-2-methyl-4,5-dihydrothiazole-4-carboxylic acid methyl ester 
• 67-56-1 methanol 
• 19791-04-9 2,2,2-trichloroethyl 3-acetyl-2,3-dihydro-2,2-dimethyl-1,3-thiazole-4-carboxylate 
• 134259-01-1 3-acetyl-2,3-dihydro-2,2-dimethyl-1,3-thiazole-4-carboxylic acid 

Downstream Products

• 20949-84-2 2-methylthiazole-4-carbaldehyde 
• 133415-15-3 methyl 2-methyl-5-phenylthiazole-4-carboxylate 
• 899897-21-3 methyl 5-bromo-2-methyl-1,3-thiazole-4-carboxylate 

Relevant articles and documents

An anhydride and β-azido disulfide simple new method for the synthesis of thiazole (by machine translation)

This invention has offered a kind of direct to anhydride and β-azido disulfide as the substrate, in the neutral organic phosphine, organic alkali reagent and oxidation under the combined action of the reagent, one-pot synthesis of high-efficient synthesis of thiazole compound new method. As shown in general formula I, the method is simple in operation, economic, anhydride available for sale in the market as the substrate, under the mild alkaline conditions, there is no need to add any coupling reagent can be conveniently completed the synthesis of thiazole compounds. (by machine translation)

Convenient Synthesis of Azolines to Azoles

Azolines are oxidized in the presence of a copper-containing catalyst to azoles in the presence of molecular oxygen. A synthetic scheme converting azolines azoles is also provided.

Mechanism selection for regiocontrol in base-assisted, palladium-catalysed direct C-H coupling with halides: First approach for oxazole- and thiazole-4-carboxylates

Both base-assisted non-concerted metallation-deprotonation (nCMD) and concerted metallation-deprotonation (CMD) have been identified as two potent operating mechanisms in palladium-catalysed direct C-H coupling of oxazole and thiazole-4-carboxylate esters