6437-67-8

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 106-93-4 ethylene dibromide 

Downstream Products

• 104845-83-2 O,O'-(ethane-1,2-diyl)bis(hydroxylamine) dihydrochloride 

Relevant academic research and scientific papers

Synthesis of novel oxa-isosteres of spermidine and spermine

3-Bromopropylamine hydrobromide reacts with N-hydroxyphthalimide in the presence of DBU to give, not the expected N-(3-aminopropyloxy)phthalimide, but N-(3-aminooxypropyl)-phthalimide, 6, formed by an unusual intramolecular rearrangement. Coupling of the pentamethyl-chroman-6-sulphonyl (Pmc) derivatives of 9 and 13 with N-Bpoc-aminopropanol affords a differentially protected 6-oxaspermidine 10 and 6,9-dioxaspermine 14 respectively from which the protecting groups are removed independently.

Hetero-trinuclear Zn(II)-M(II) (M = Sr, Ba) complexes based on a mononuclear Zn(II) complex metallohost: Syntheses, structures and fluorescence properties

A new mononuclear Zn(II) complex, [ZnL(HOAc)] (1) (H2L = 6,6′-diethoxy-2,2′-[1,2-ethylenedioxybis(nitrilomethylidyne)]diphenol), was synthesized by reaction of H2L and Zn(II) acetate under solvothermal conditions. Complex 1 acts as a metallohost possessing a pentadentate O5 donor. Complex 1 molecules bonded to one Sr(II) or Ba(II) form two new hetero-trinuclear complexes, [(ZnL)2M(OAc)2] (M = Sr (2), Ba (3)). In 2 and 3, Zn(II) ions are 5-coordinate, but the Sr(II) or Ba(II) ion is 10-coordinate by four μ-phenolic oxygens from two L2-units, four oxygens from four ethoxy groups and two oxygens from two μ-acetato ligands. Furthermore, 1-3 exhibit blue emissions with the maximum emission wavelengths λmax = 477, 500, and 471 nm when excited at 360 nm.

A highly efficient strategy for modification of proteins at the C terminus

A new linker: In a facile, chemoselective, and potentially general method for protein modification at the C terminus oxyamino-modified proteins obtained from protein thioesters react rapidly with ketones under mild conditions. This strategy was used for fluorescence labeling, for example with modified coumarin and fluorescein (see scheme). Copyright

A novel pyridine-containing half-salamo-based “on-off-on” fluorescent sensor for continuous detecting Cu2+ and S2?, and its structural features of copper(II) complex

A novel sensor PNS for the continuous recognition of Cu2+ and S2? was synthesized, specifically recognizes Cu2+ in DMSO/H2O (9:1 v/v) solution by fluorescence emission spectroscopy. The colour of the PNS solution changed from colourless to yellow when Cu2+ was added under the fluorescent lamp, and at excitation wavelengths of 301 and 365 nm, the violet fluorescence of the PNS solution was quenched. The PNS-Cu complex formed by the sensor PNS and Cu2+ can further identify S2? in the fluorescence spectra. The LOD values of the two substances both Cu2+ and S2? are 1.21 × 10?8 and 5.58 × 10?9 M. In addition, single crystals of the PNS-Cu complex were also obtained to verify the principle of this continuous identification process.

Uracil-directed ligand tethering: An efficient strategy for uracil DNA glycosylase (UNG) inhibitor development

Uracil DNA glycosylase (UNG) is an important DNA repair enzyme that recognizes and excises uracil bases in DNA using an extrahelical recognition mechanism. It is emerging as a desirable target for small-molecule inhibitors given its key role in a wide ran

Co(II) and Ni(II) bis(salamo)-based tetraoxime complexes: Syntheses, structural characterizations, fluorescence properties, and Hirshfeld analyses

Two new asymmetric complexes with the chemical structural formulas [{Co2(L)(μ 2-OH)}{Co2(L)(OAc)(CH3OH)}{Co2(L)(μ 2-OCH3)}{Co2(L)(μ 2-OAc)}]?4CH3

A family of salamo-type trinuclear Co(II) and Ni(II) complexes: Structural characterization, Hirshfeld surface analysis and fluorescent properties

Three trinuclear complexes, [{CoL(MeOH)(μ-OAc)}2Co] (1), [{CoL(EtOH)(μ-OAc)}2Co]·2CH3CH2OH (2) and [{NiL(MeOH)(μ-OAc)}2Ni]·2CH3OH (3) have been successfully synthesized by wet-chemical meth

Heterobimetallic 3d–4f Zn(II)–Ln(III) (Ln?=?Sm, Eu, Tb and Dy) complexes with a N2O4 bisoxime chelate ligand and a simple auxiliary ligand Py: Syntheses, structures and luminescence properties

Four new 3d–4f heterobinuclear complexes [Zn(L)Sm(Py)(NO3)3] (1), [Zn(L)Eu(OAc)(NO3)2] (2), [Zn(L)Tb(Py)(NO3)3] (3) and [Zn(L)Dy(OAc)(NO3)2] (4); Py?=?pyridine; H

Studying anion-dependent paradoxically fluorescent Cu(II) complexes bearing a pyridine-decorated tetradentate half-salamo-like ligand

A new pyridine-decorated half-salamo-like ligand (HL) was designed and synthesized by a one-pot method. Based on this ligand, the single crystals of three anion-dependent Cu(II) complexes [Cu(L)Cl]·CH3OH (1), [Cu(L)Br] (2) and [Cu(L)(NO3/

A unitary fluorescence probe to sense Co2+: Validated by theoretical studies and X-ray crystallography

A new salamo-type fluorescence probe H2L was synthesized by a series of reactions and corroborated by single-crystal X-ray crystallography and 1H NMR spectra. Fluorescence of Co2+ selectively response showed “off” when cat