2,2'-(Ethane-1,2-diylbis(oxy))bis(isoindoline-1,3-dione)

Base Information

• Chemical Name: 2,2'-(Ethane-1,2-diylbis(oxy))bis(isoindoline-1,3-dione)
• CAS No.: 6437-67-8
• Molecular Formula: C₁₈H₁₂N₂O₆
• Molecular Weight: 352.303
• European Community (EC) Number: 661-894-1
• DSSTox Substance ID: DTXSID10367237
• Wikidata: Q82152956
• Mol file: 6437-67-8.mol

Synonyms:6437-67-8;2,2'-(Ethane-1,2-diylbis(oxy))bis(isoindoline-1,3-dione);N,N'-(Ethylenedioxy)di-phthalimide;2-[2-(1,3-dioxoisoindol-2-yl)oxyethoxy]isoindole-1,3-dione;N,N'-(Ethylenedioxy)diphthalimide;MS-0459;CBDivE_002630;1,2-Bis(phthalimidooxy)ethane;NIOSH/TI5080000;SCHEMBL22326350;DTXSID10367237;N,N/'-(Ethylenedioxy)diphthalimide;AKOS002684650;Phthalimide, N,N'-(ethylenedioxy)di-;SB65704;LS-109471;FT-0668258;TI50800000;SR-01000196581;SR-01000196581-1;N,N inverted exclamation mark -(Ethylenedioxy)di-phthalimide;2-{2-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)oxy]ethoxy}-2,3-dihydro-1H-isoindole-1,3-dione

Chemical Property of 2,2'-(Ethane-1,2-diylbis(oxy))bis(isoindoline-1,3-dione)

Chemical Property:

• Melting Point: 249-215°C
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Ethyl Acetate (Slightly)
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 352.06953611
• Heavy Atom Count: 26
• Complexity: 533

Purity/Quality:

97% ^*data from raw suppliers

2-(2-((1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)OXY)ETHOXY)-1H-ISOINDOLE-1,3(2H)-DIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)OCCON3C(=O)C4=CC=CC=C4C3=O
• Uses: Byproduct of Phthalimide alkylation.

Technology Process of 2,2'-(Ethane-1,2-diylbis(oxy))bis(isoindoline-1,3-dione)

There total 2 articles about 2,2'-(Ethane-1,2-diylbis(oxy))bis(isoindoline-1,3-dione) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-hydroxyphthalimide (524-38-9) + ethylene dibromide (106-93-4) → N,N’-(ethylenedioxy)diphthalimide (6437-67-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 16h;

Reference yield:

→ N,N’-(ethylenedioxy)diphthalimide (6437-67-8)

Guidance literature:

N-Hydroxy-phthalimid, Ethylenbromid, Triethylamin, in Dimethylformamid, 25grad, 17h;

DOI:10.1021/jo01041a042

Reference yield: 46.0%

N,N’-(ethylenedioxy)diphthalimide (6437-67-8) → O,O'-(ethane-1,2-diyl)bis(hydroxylamine) dihydrochloride (104845-83-2)

Guidance literature:

With hydrogenchloride; acetic acid; In water; at 100 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.inorgchem.0c01156

upstream raw materials:

N-hydroxyphthalimide

ethylene dibromide

Downstream raw materials:

O,O'-(ethane-1,2-diyl)bis(hydroxylamine) dihydrochloride