643762-61-2

Upstream product

• 375368-83-5 3-bromo-6-fluoro-2-methyl-pyridine 
• 42753-71-9 5-bromo-6-methyl-pyridin-2-ylamine 

Downstream Products

• 643762-62-3 (3-bromo-6-fluoro-pyridin-2-ylmethyl)-(4-methoxy-benzyl)-amine 
• 1403741-03-6 6-fluoro-3-(4-methoxy-benzyl)-1-phenyl-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-2-one 
• 1403741-02-5 1-(3-bromo-6-fluoro-pyridin-2-ylmethyl)-1-(4-methoxy-benzyl)-3-phenyl-urea 
• 643762-64-5 1-[3-bromo-6-(2-chloro-4-fluoro-phenylsulfanyl)-pyridin-2-ylmethyl]-3-(2,6-dichloro-phenyl)-1-(4-methoxy-benzyl)-urea 
• 547756-24-1 1-(2,6-dichloro-phenyl)-6-(2,4-difluoro-phenylsulfanyl)-3-(4-methoxy-benzyl)-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-2-one 
• 720665-79-2 6-(2-chloro-4-fluoro-phenylsulfanyl)-1-(2,6-dichloro-phenyl)-3-(4-methoxy-benzyl)-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-2-one 

Relevant academic research and scientific papers

BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY

The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2, R3, A, W, U and

SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors

Development for a class of potent 3,4-dihydropyrido(3,2-d)pyrimidone inhibitors of p38a MAP kinase is described. Modification of N-1 aryl and C-6 arylsulfide in 3,4-dihydropyrido(3,2-d)pyrimidone analogues for the interaction with the hydrophobic pockets