64402-51-3

Upstream product

• 873-67-6 benzonitrile oxide 
• 7647-01-0 hydrogenchloride 
• 145665-04-9 5-hydroxy-5-(β-hydroxyimino-β-phenylethyl)-3-phenyl-2-isoxazoline 
• 613-91-2 acetophenone oxime 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 6797-27-9 3-phenyl-5-(phenylethynyl)isoxazole 
• 17994-49-9 3,8-diphenyl-1,6-dioxa-2,7-diaza-spiro[4.4]nona-2,7-diene 
• 53085-53-3 5-(β-hydroxyimino-β-phenylethyl)-3-phenylisoxazole 
• 107451-76-3 1,5-diphenylpent-1-yne-3,5-dione 

Downstream Products

• 65-85-0 benzoic acid 
• 86739-45-9 4-Bromo-5-hydroxy-1-(4-nitro-phenyl)-3-phenyl-pyridazin-1-ium; bromide 
• 86739-46-0 4-Bromo-5-hydroxy-1,3-diphenyl-pyridazin-1-ium; bromide 
• 86739-47-1 C₁₆H₁₀BrN₃O₃ 
• 86739-48-2 C₁₆H₁₁BrN₂O 
• 86739-41-5 3-phenyl-p-nitrophenylhydrazone-5-phenylisoxazole 
• 86739-42-6 N-Phenyl-N'-[1-phenyl-2-(3-phenyl-isoxazol-5-yl)-eth-(Z)-ylidene]-hydrazine 
• 14442-12-7 3-phenylisoxazole-5-carboxylic acid 
• 99466-20-3 1,3-diphenyl-5-phenacylpyrazole 

Relevant academic research and scientific papers

A new synthesis of 5-hydroxy-2-isoxazolines and their conversion into isoxazoles

The reaction of 1,5-diarylpent-1-yne-3,5-diones (1) or 2,6-diaryl-4H-pyran-4-ones (2) with hydroxylamine in ethanol leads to the formation of 5-hydroxyisoxazolines (3,6) along isoxazoles (7,8) as minor products.The isoxazolines can be converted into isoxa

The Preparation of 5-Phenacylisoxazoles and 5-Hydroxyphenylisoxazoles and -pyrazoles by the Condensation of C(α)-Dianions with Ethyl Benzoylacetate and Methyl Salicylate

C(α),O-Dilithiooximes and C(α),N-Dilithiophenylhydrazones were prepared in an excess of lithium diisopropylamide (LDA).The former was condensed with ethyl benzoylacetate and methyl salicylate, and the latter condensed with methyl salicylate.The resulting precyclization intermediates were than treated with aqueous acid, which was followed by cyclodehydration to give phenacylisoxazoles and hydroxyphenylisoxazoles and -pyrazoles.

HYDRATION AND HYDROGENATION OF ACETYLENIC SIDE-CHAINS AT THE 4- OR 5-POSITION OF ISOXAZOLES

Hydration of 5-isoxazolyl-phenyl(or -butyl)acetylenes (1a, b) in dilute sulfuric acid in the presence of mercuric sulfate afforded 5-isoxazolylmethyl phenyl (or butyl) ketones (3a, b), predominantly.In contrast, the hydration of 4-isoxazolyl-phenyl(or -bu