64411-39-8

Upstream product

• 15761-39-4 N-tert-butoxycarbonyl-proline 
• 108-95-2 phenol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 147-85-3 L-proline 
• 86953-79-9 tert-butyl pyrrolidine-1-carboxylate 
• 1885-14-9 phenyl chloroformate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 

Downstream Products

• 1384256-83-0 phenyl 1-(3-(biphenyl-4-yloxy)-3-oxoprop-1-enyl)pyrrolidine-2-carboxylate 
• 1393821-79-8 C₃₃H₃₄N₃O₃P 
• 1393821-80-1 C₃₀H₃₆N₃O₃P 
• 1393821-81-2 C₃₈H₄₃N₄O₅P 
• 1393821-82-3 C₂₈H₃₁N₄O₄P 
• 1393821-70-9 diphenylphosphine proline phenyl ester 
• 1393821-83-4 C₃₄H₄₁N₄O₇P 
• 1393821-84-5 C₃₃H₄₀N₃O₅P 
• 1393821-85-6 C₃₉H₅₂N₅O₆P 
• 1393821-86-7 C₄₃H₅₈N₅O₈P 
• 1393821-87-8 C₂₃H₂₃N₂O₂P 
• 116774-46-0 (S)-N-Benzylpyrrolidine-2-carboxyamide 
• 1393821-67-4 C₂₄H₂₅N₂O₂P 
• 220510-58-7 tert-butyl (S)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Mechanically induced solvent-free esterification method at room temperature

Herein, we describe two novel strategies for the synthesis of esters, as achieved under high-speed ball-milling (HSBM) conditions at room temperature. In the presence of I2 and KH2PO2, the reactions afford the desired esterification derivatives in 45% to 91% yields within 20 min of grinding. Meanwhile, using KI and P(OEt)3, esterification products can be obtained in 24% to 85% yields after 60 min of grinding. In addition, the I2/KH2PO2 protocol was successfully extended to the late-stage diversification of natural products showing the robustness of this useful approach. Further application of this method in the synthesis of inositol nicotinate was also discussed. This journal is

Direct C-C Bond Formation from Alkanes Using Ni-Photoredox Catalysis

A method for direct cross coupling between unactivated C(sp3)-H bonds and chloroformates has been accomplished via nickel and photoredox catalysis. A diverse range of feedstock chemicals, such as (a)cyclic alkanes and toluenes, along with late-stage intermediates, undergo intermolecular C-C bond formation to afford esters under mild conditions using only 3 equiv of the C-H partner. Site selectivity is predictable according to bond strength and polarity trends that are consistent with the intermediacy of a chlorine radical as the hydrogen atom-abstracting species.

SINGLET OXYGEN-LABILE LINKERS AND METHODS OF PRODUCTION AND USE THEREOF

Activatable compositions that include at least one functional moiety and at least one cleavable linker directly or indirectly linked to the at least one functional moiety are disclosed. The at least one functional moiety is inactive when linked to the linker and activated upon cleavage of the linker. Methods of production and use of the activatable composition are also disclosed.

A proline-based phosphine template for Staudinger ligation

A proline-based phosphine template enabling a rapid Staudinger ligation of azide-containing substrates under mild conditions is reported. This reaction has a second-order rate constant of 1.12 M-1 s-1. It is expected that the proline

Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release

"Click and Photo-unclick Chemistry" of aminoacrylates is proposed for a new photo-labile linker. Adducts are built in 2 steps with good yields and cleaved rapidly by tissue penetrable visible light (690 nm) with a photosensitizer. Facile synthesis, release of mother drug, and stability and cleavage in medium are demonstrated.

ACTIVATION OF A CARBOXY GROUP BY DIALKYL PYROCARBONATES. SYNTHESIS OF SYMMETRICAL ANHYDRIDES AND ARYL ESTERS OF N-PROTECTED AMINO ACIDS USING DI-tert-BUTYL PYROCARBONATE AS CONDENSING REAGENT

It has been shown that di-tert-butyl pyrocarbonate can be used as a condensing reagent in the production of anhydrides and some aryl esters of carboxylic acids.The synthesis of anhydrides and of phenyl, p-nitrophenyl, β-naphtyl, and quinolin-8-yl esters of N-protected amino acids is described.