64516-59-2

Upstream product

• 98-86-2 acetophenone 
• 100-42-5 styrene 
• 14804-59-2 3-bromo-3-phenylacrylaldehyde 
• 67-56-1 methanol 
• 64516-55-8 4,4-diphenylpyran 
• 64516-56-9 1,1,5,5-tetramethoxy-3,3-diphenylpentane 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 14035-53-1 3-hydroxy-3,5-diphenylpent-4-enylidenecyclohexylamine 
• 345207-96-7 2,6-dichloro-4,4-diphenyltetrahydro-2,3,5,6-thiopyran 

Downstream Products

• 26274-35-1 2,4-diphenylpyridine 
• 81699-57-2 (2Z,4E)-3,5-Diphenyl-penta-2,4-dienoic acid 

Relevant academic research and scientific papers

Atroposelective Arene Formation by Carbene-Catalyzed Formal [4+2] Cycloaddition

Atroposelective arene formation is an efficient method to build axially chiral molecules with multi-substituted arenes. Reported here is an organocatalyzed atroposelective arene formation reaction by an N-heterocyclic carbene (NHC) catalyzed formal [4+2] cycloaddition of conjugated dienals and α-aryl ketones. This study expands the synthetic potential of NHC organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts, and other functional molecules.

N-heterocyclic carbene-catalyzed δ-Carbon LUMO activation of unsaturated aldehydes

An N-heterocyclic carbene (NHC) catalyzed domino reaction triggered by a δ-LUMO activation of α,β-γ,δ-diunsaturated enal has been developed for the formal [4 + 2] construction of multisubstituted arenes and 3-ylidenephthalide. These two products, formed i

A modular approach toward the synthesis of 2,4-disubstituted pyridines

A number of 2,4-disubstituted pyridines have been synthesized using α,β,γ,δ-unsaturated aldehydes and ammonium chloride in the presence of triethylamine in acetonitrile solvent at 80 C under air balloon.

Vinylogous organocatalytic triple cascade reaction: Forging six stereocenters in complex spiro-oxindolic cyclohexanes

We report a triple vinylogous cascade reaction, yielding valuable spiro-oxindolic cyclohexane derivatives. The three-component domino process proceeds by way of a catalyzed Michael/1,6-addition/vinylogous aldol sequence affording the products with six stereogenic centers and very high control over the stereochemistry. The chemistry is based on a rare example of asymmetric 1,6-addition to linear 2,4-dienals proceeding with complete δ-site selectivity. Key to the reaction development was a directing group positioned at the β-dienal position, which was essential for achieving highly predictable reaction outcomes. Copyright

On the origin of regioselectivity in the photorearrangement of 4,4-diphenyl-2,5-cyclohexadiene systems. Synthesis and photochemistry of 4,4-diphenyl-γ-thiopyran and -γ-thiopyran-1,1-dioxide

The synthesis from diphenylmethane of 4,4-diphenyl-γ-thiopyran and 4,4-diphenyl-γ-thiopyran-1,1-dioxide is described.Upon direct photolysis at 254 nm the γ-thiopyran derivative undergoes rearrangement to a mixture of 5,6-diphenyl-2-thiabicyclohexen