64536-04-5

Upstream product

• 414871-77-5 C₃₆H₄₈O₆S₂ 
• 110-86-1 pyridine 
• 68-26-8 RETINOL 
• 75-36-5 acetyl chloride 
• 14918-80-0 3-methyl-4-oxobut-2-enyl acetate 
• 55497-46-6 1,5,5-trimethyl-6-(3-methyl-penta-2,4-dienylidene)-cyclohexene 
• 108-24-7 acetic anhydride 
• 105096-76-2 1-hydroxy-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-9-phenylsulfonyl-2,6,8-nonatriene 
• 103905-08-4 1-acetoxy-6-chloro-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-9-phenylsulfonyl-2,7-nonadiene 
• 103905-09-5 1-acetoxy-6-bromo-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-9-phenylsulfonyl-2,7-nonadiene 
• 3230-76-0 10,15-dihydroxy-9,13-dimethyl-7-(1,1,5-trimethyl-5-cyclohex-6-enyl)-8,11,13-nonatriene 
• 139697-15-7 Acetic acid (2Z,4Z,6E)-8-chloro-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6-trienyl ester 
• 120591-27-7 (+/-)-(E,E,E)-9-(acetyloxy)-3,7-dimethyl-1-<2,6,6-trimethyl-1-cyclohexen-1-yl>-1,5,7-nonatrien-4-one 
• 26586-02-7 (E)-4-acetoxy-2-methylcrotonaldehyde 

Downstream Products

• 166584-44-7 Acetic acid (3E,5E,7E)-(1S,2S)-1-acetoxymethyl-2-hydroxy-2,6-dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,5,7-trienyl ester 
• 29444-27-7 9cis,13cis-retinyl acetate 
• 137121-50-7 7-cis-retinyl acetate 
• 137121-51-8 Acetic acid (2E,4Z,6E,8Z)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester 
• 137121-54-1 Hexadecanoic acid (2E,4Z,6E,8Z)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester 
• 137121-53-0 Hexadecanoic acid (2E,4E,6E,8Z)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester 
• 137121-52-9 (7Z,11Z)-Vitamin A 
• 6018-74-2 (7Z)-Vitamin A 
• 7235-40-7 beta-carotene 
• 22255-47-6 (E)-2-(3-methylbuta-1,3-dienyl)-1,3,3-trimethyl-cyclohex-1-ene 
• 43219-55-2 (1E,3E)-3-methyl-1-[2,6,6-trimethylcyclohex-1-enyl]hexa-1,3,5-triene 
• 70244-78-9 2-((1E,3E,5E)-3,7-dimethylocta-1,3,5,7-tetraen-1-yl)-1,3,3-trimethylcyclohex-1-ene 
• 1254107-61-3 3'(14'-apo-β-carotene-14'-carbonyl)daidzein 
• 56859-10-0 1-[(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraene-1-sulfonyl]-4-phenoxy-benzene 

Relevant academic research and scientific papers

Preparation method of vitamin A acetate

The invention provides a novel preparation method of vitamin A acetate, which comprises the following steps: 1-bromo-2-chloroethane is subjected to in-situ preparation of a Grignard reagent, then the Grignard reagent reacts with pentacarbaldehyde to prepare 3-methyl-6-chloro-2, 4-hexadienol acetate, and the 3-methyl-6-chloro-2, 4-hexadienol acetate is subjected to one-step in-situ Grignard reaction and beta-ionone reaction to obtain the vitamin A acetate. The process provides a C13 + C7 vitamin A acetate synthesis route, generation of triphenylphosphine oxide is avoided, modification solid acid is used for catalysis, VA deterioration is avoided, the yield of the vitamin A acetate is improved, the process cost is reduced, the reaction process is environmentally friendly, and industrial production is facilitated. The process cost is reduced, the reaction process is environment-friendly, and industrial production is facilitated.

METHOD FOR SYNTHESISING VITAMIN A

A method for preparing a compound of formula (I) in which R1 is selected from H and alkyls, R2 is selected from H, alkyls, OR′ where R′ is selected from alkyls, silyls, CO-alkyl, R3 is selected from the acyl groups of the CO(R″) type, and the CO(OR″), CO(

PROCESS FOR PRODUCTION OF VITAMIN A

The present invention relates to a new process for the production of vitamin A and/or its derivatives.

PROCESS FOR PRODUCTION OF NEW SULFOLENIC INTERMEDIATES

The present invention relates to a new process for the production of new specific intermediates, which are preferably used in the production of vitamin A, vitamin A acetate, or β-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin.

Preparation method of vitamin A acetate

The invention provides a preparation method of vitamin A acetate, which comprises the following steps: reacting bromoethanol with acetone to obtain a ketal compound, preparing a Grignard reagent fromthe ketal compound, reacting the Grignard reagent with C5 aldehyde to obtain heptanol, reacting the heptanol with triphenylphosphine to prepare heptacarbon phosphine salt, and further reacting the heptacarbon phosphine salt with ionone to obtain the vitamin A acetate. According to the present invention, a C13 + C7 vitamin A acetate synthesis route is provided, such that the yield of the vitamin Aacetate is improved, the process cost is reduced, and the industrial production is easily achieved.

Preparation method of vitamin A acetate

The invention discloses a preparation method of vitamin A acetate. Thepreparation method is characterized in that raw materials including vinyl ionol, an organic phosphine compound and pentacarbonaldehyde react under the action of a catalyst to generate vitamin A acetate, and the vitamin A acetate is synthesized by adopting a one-step method. According to the invention, the problems of considerable byproducts, serious equipment corrosion and the like caused by a liquid acid catalyst in a reaction are avoided; and meanwhile, the defects of large dosage of a base catalyst, difficulty in waste alkali treatment and the like are overcome.

ISOMERIZATION OF POLYUNSATURATED NON-AROMATIC COMPOUNDS

The invention relates to an improved process for isomerizing polyunsaturated non-aromatic compounds including acyclic conjugated polyenes and alicyclic conjugated polyenes. In particular it relates to an improved and safe process for forming a 11-E retinoid compounds in high yield by expending as few energy as possible and with avoiding at most possible side products or product mixtures. This is achieved by feeding at least one of retinoid compounds of formula 2 to 5, or at least one of retinoid compounds of formula 2 to 5 and retinoid compound of formula 1, an organic solvent and a photosensitizer into a reaction device and irradiating the thus obtained reaction mixture with visible monochromatic light, at least 90 % of the power of said monochromatic light and at most 100 % of said power being emitted in the range from 460 nm to 580 nm.

Preparation method of vitamin A acetate

The invention belongs to the field of organic synthesis and discloses a method for preparing vitamin A acetate. The method comprises the following steps that: in the presence of crown ether, a first Wittig reaction is carried out on C14 aldehyde trans-2-methyl-4-(2, 6, 6-trimethyl-1-cyclohexene)-2-butenal and C1 phosphate (tetraethyl methylenediphosphate or tetramethyl methylenediphosphate) in thepresence of organic alkali to obtain a material containing C15 phosphate, wherein R is selected from C1-C3 alkyl groups, preferably ethyl groups; and (2) the material containing C15 phosphate obtained in the step (1) and C5 aldehyde 2-methyl-4-acetoxy-2-butenal are subjected to a second Wittig reaction so as to obtain a reaction liquid containing the vitamin A acetate. The method has the advantages of environmental friendliness and high yield, and provides convenience for large-scale production of the vitamin A acetate.

SPECIFIC DEHYDROGENATION PROCESS (I)

The present invention relates to a new dehydrogenation process of specific compounds.

Preparation method of vitamin A acetate intermediate C15 and vitamin A acetate

The invention provides a preparation method of a vitamin A acetate intermediate C15 and vitamin A acetate. The method comprises the following steps: taking 1-halogenated-2-methyl-4-acetoxy-2-butene asa raw material, preparing a corresponding Wittig reagent through a substitution reaction with triphenylphosphine or triester phosphite, then carrying out a Wittig reaction with beta-cyclocitral, hydrolyzing an ester group under an alkaline condition, acidifying to obtain a corresponding halide, and carrying out a substitution reaction with triphenylphosphine or triester phosphite again to prepareC15. The vitamin A acetate can be prepared by carrying out a Wittig reaction on the obtained C15 and 2-methyl-4-acetoxy-2-butenal under an alkaline condition. The method has the advantages of singlereaction type, easy operation and realization of reaction conditions, safe and environment-friendly operation, simple post-treatment and low cost; and the reaction activity is strong, the reaction selectivity is high, the atom economy is high, and the target product yield and purity are high.