645396-81-2

Upstream product

• 100-52-7 benzaldehyde 
• 645396-79-8 (3E,4aR,10aR)-3-benzylidene-4a-ethyl-7-hydroxy-3,4,4a,9,10,10a-hexahydro-1H-phenanthren-2-one 
• 645396-80-1 (2S,3E,4aR,10aR)-3-benzylidene-4a-ethyl-2-phenyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-2,7-diol 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 645396-84-5 (2R,4aR,10aR)-4a-ethyl-2,7-dihydroxy-2-phenyl-1,2,4,4a,10,10a-hexahydrophenanthren-3(9H)-one 
• 645396-82-3 (2R,4aR,10aR)-7-(4-nitrobenzoyloxy)-4a-ethyl-2-hydroxy-2-phenyl-1,4,4a,9,10,10a-hexahydro-2H-phenanthren-3-one 
• 645396-83-4 (2R,4aR,10aS)-7-(4-nitrobenzoyloxy)-4a-ethyl-2-hydroxy-2-phenyl-1,2,4,4a,10,10a-hexahydrophenanthrene-3,9-dione 

Relevant academic research and scientific papers

2-Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as potent dissociated glucocorticoid receptor agonists

A significant improvement in agonist activity of the previously described 2-aryloctahydrophenanthrene-2,3,7-triol series of dissociated glucocorticoid receptor agonists (DAGRs) was achieved by modifying the substitution at C3 from (S)-3-hydroxy to (R)-3-h

MODULATORS OF THE GLUCOCORTICOID RECEPTOR

The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1-R25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment o