64583-19-3

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 73584-06-2 diethyl α-chloro-4-fluorobenzylphosphonate 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 2266-41-3 4-fluorobenzenesulfonylhydrazide 
• 934-94-1 1-bromo-4-bromoethynyl-benzene 
• 459-57-4 4-fluorobenzaldehyde 
• 189099-56-7 diphenyl chloro(4-bromophenyl)methylphosphonate 

Downstream Products

• 64608-28-2 1-(4-bromostyryl)-4-fluorobenzene 
• 38695-36-2 (E)-1-bromo-4-(4-fluorostyryl)benzene 
• 167858-22-2 1-(4-fluorophenyl)-2-[4-(1-trans-pentenyl)phenyl]acetylene 

Relevant academic research and scientific papers

Highly efficient synthesis of 1,2-disubstituted acetylenes derivatives from the cross-coupling reactions of 1-bromoalkynes with organotitanium reagents

A Highly efficient route for the synthesis of 1,2-disubstituted acetylene derivatives has been developed by nickel catalyzed cross-couplings of alkynyl halides with aryl titanium reagents under mild conditions. This has given corresponding cross-coupling products good to excellent isolated yields of up to 92 %. The aryls bearing electron-donating or electron-withdrawing groups in either alkynylhalides or aryltitanium substrates gave cross-coupling products good yields. This process was simple and easily performed, which provides an efficient method for the synthesis of 1,2-disubstituted acetylenes derivatives.

Palladium-Catalyzed Desulfitative Cross-Coupling of Arylsulfonyl Hydrazides with Terminal Alkynes: A General Approach toward Functionalized Internal Alkynes

A palladium-catalyzed Sonogashira-type coupling between arylsulfonyl hydrazides and terminal alkynes via Ar(C)-S bond cleavage is disclosed, which enables the general synthesis of functionalized internal alkynes, especially the Br-substituted ones, in good to excellent yields under acid- and base-free conditions.

Synthesis and non-linear properties of disubstituted diphenylacetylene and related compounds

A variety of disubstituted diphenylacetylenes and related compounds have been synthesized by a modified Horner-Emmons reaction, and their second harmonic generation (SHG) has been evaluated by the Kurtz powder method. The diphenylacetylenes with weak electron-donating and -withdrawing groups are found to be efficient for SHG, as well as having the lowest cut-off wavelength.