64598-39-6

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 89-25-8 edaravone 
• 59-88-1 phenylhydrazine hydrochloride 
• 100-63-0 phenylhydrazine 

Downstream Products

• 1078132-19-0 C₂₄H₁₈ClFN₂O₂ 
• 1078132-21-4 C₂₄H₁₈ClN₃O₄ 
• 1078132-20-3 C₂₄H₁₉ClN₂O₂ 
• 133176-03-1 (5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)(4-chlorophenyl)methanone 

Relevant academic research and scientific papers

Pyrazole and Triazole Derivatives as Mycobacterium tuberculosis UDP-Galactopyranose Inhibitors

UDP-galactopyranose mutase (UGM) is an essential enzyme involved in the bacterial cell wall synthesis, and is not present in mammalian cells. Thus, UGM from Mycobacterium tuberculosis (Mtb) represents a novel and attractive drug target for developing antituberculosis agents. A pyrazole-based compound, MS208, was previously identified as a mixed inhibitor of MtbUGM which targets an allosteric site. To understand more about the structure activity relationship around the MS208 scaffold as a MtbUGM inhibitor, thirteen pyrazoles and triazole analogues were synthesized and tested against both MtbUGM and Mycobacterium tuberculosis in vitro. While the introduced structural modifications to MS208 did not improve the antituberculosis activity, most of the compounds showed MtbUGM inhibitory activity. Interestingly, the pyrazole derivative DA10 showed a competitive model for MtbUGM inhibition with improved Ki value of 51 ± 4 μM. However, the same compound did not inhibit the growth of Mycobacterium tuberculosis.

Toner and charge control agent using pyrazolone derivative or salt of derivative

The purpose of the present invention is to provide a charge control agent for polymerized toners and particularly for color toners, which has a large charge amount and environmentally stable charging characteristics. Since a charge control agent including

Synthesis, Structure, and Biological Activities of [5-(Arylthio/sulfinyl/sulfonyl)-3-methyl-1-phenyl-1 H -pyrazol-4-yl]-arylmethanones

A series of novel N-phenylpyrazolyl aryl methanones derivatives containing the arylthio/sulfinyl/sulfonyl group have been synthesized via multi-step reactions from 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one and characterized by melting point, 1H NM

Synthesis and herbicidal activity of acylpyrazole derivatives containing 1,2,3-thiadiazole moiety

A series of novel acylpyrazole derivatives containing 1,2,3-thiadiazole ring 3a-3m were synthesized by the condensations of 1-phenyl-3-methyl-4- (substituted benzal or 4-methyl-1,2,3-thiadiazole-5-carbonyl)-5-hydroxypyrazole 2 with 4-methyl-1,2,3-thiadiaz